Keltz Martin D, Stein Daniel E, Berin Inna, Skorupski Josh
Department of Obstetrics and Gynecology, St. Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY 10019, USA.
J Reprod Med. 2012 Jan-Feb;57(1-2):9-12.
To determine whether a progesterone-to-estradiol (P/E2) ratio on day of human chorionic gonadotropin (hCG) administration would be a better predictor of in vitro fertilization (IVF) outcome than serum P alone.
All 348 fresh IVF cycles performed in 2002 and 2003 at a university hospital center were reviewed for all cycle parameters as related to the peak P and peak P/E2 ration on day hCG administration.
Out of the 348 cycles performed, 199 cycles resulted in clinical pregnancies. The mean P level (1.4 ng/mL) was equivalent in both conception and nonconception cycles. A P/E2 ratio > 1.0, however, was associated with a highly significant reduction in clinical pregnancy rate (38.2% vs. 62.6%, p< 0.01) and live birth rate (35.4% vs. 49.1%, p = 0.02).
Cycles with elevated P/E2 ratios are associated with lower clinical pregnancy and live birth rates, which decrease further as the P/E2 ratio rises. P/E2 ratio improves the prediction of IVF outcome when compared to serum P levels alone.
确定在注射人绒毛膜促性腺激素（hCG）当天的孕酮与雌二醇（P/E2）比值是否比单独的血清孕酮水平能更好地预测体外受精（IVF）结局。
回顾了2002年和2003年在一家大学医院中心进行的所有348个新鲜IVF周期，分析了与hCG注射当天的孕酮峰值和P/E2峰值相关的所有周期参数。
在进行的348个周期中，199个周期临床妊娠。妊娠周期和未妊娠周期的平均孕酮水平（1.4 ng/mL）相当。然而，P/E2比值>1.0与临床妊娠率（38.2%对62.6%，p<0.01）和活产率（35.4%对49.1%，p = 0.02）的显著降低相关。
P/E2比值升高的周期与较低的临床妊娠率和活产率相关，且随着P/E2比值升高，这些比率进一步降低。与单独的血清孕酮水平相比，P/E2比值能更好地预测IVF结局。
