定义临床瘦素抵抗的挑战和机遇。
Challenges and opportunities of defining clinical leptin resistance.
机构信息
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA.
出版信息
Cell Metab. 2012 Feb 8;15(2):150-6. doi: 10.1016/j.cmet.2012.01.002.
Abstract
The widespread use of the inadequately defined term "leptin resistance" led the National Institutes of Health to convene a workshop aimed at developing a quantitative definition of this term that would facilitate mechanistic research into leptin's actions in human health and disease. Although leptin-responsive conditions are recognized, the field is limited by a lack of robust, easily quantifiable behavioral or metabolic biomarkers of the hormone's action. Further advances require biomarkers that can be used to identify patients who may benefit from leptin therapy and that are useful for understanding the determinants of clinical leptin responsiveness.
摘要
“瘦素抵抗”这一术语的广泛使用是不充分的，这导致美国国立卫生研究院召开了一次研讨会，旨在为这个术语制定一个定量的定义，这将有助于研究瘦素在人类健康和疾病中的作用的机制。尽管已经认识到了瘦素反应性疾病，但该领域缺乏强大、易于量化的激素作用的行为或代谢生物标志物，这限制了该领域的发展。进一步的进展需要能够识别可能受益于瘦素治疗的患者的生物标志物，并且对于理解临床瘦素反应性的决定因素也是有用的。
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