Faculty of Biotechnology, College of Applied Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea.
Cancer Lett. 2012 Aug 28;321(2):144-53. doi: 10.1016/j.canlet.2012.01.045. Epub 2012 Feb 7.
Ginsenoside F2 (F2) was assessed for its antiproliferative activity against breast cancer stem cells (CSCs). F2 induced apoptosis in breast CSCs by activating the intrinsic apoptotic pathway and mitochondrial dysfunction. Concomitantly, F2 induced the formation of acidic vesicular organelles, recruitment of GFP-LC3-II to autophagosomes, and elevation of Atg-7 levels, suggesting that F2 initiates an autophagic progression in breast CSCs. Treatment with an inhibitor of autophagy enhanced F2-induced cell death. Our findings provide new insights into the anti-cancer activity of F2 and may contribute to the rational use and pharmacological study of F2.
人参皂苷 F2（F2）被评估其对乳腺癌干细胞（CSCs）的抗增殖活性。F2 通过激活内在凋亡途径和线粒体功能障碍诱导乳腺癌 CSCs 凋亡。同时，F2 诱导酸性囊泡细胞器的形成，GFP-LC3-II 募集到自噬体，以及 Atg-7 水平的升高，表明 F2 启动了乳腺癌 CSCs 的自噬进程。自噬抑制剂的处理增强了 F2 诱导的细胞死亡。我们的研究结果为 F2 的抗癌活性提供了新的见解，并可能有助于 F2 的合理使用和药理学研究。
