Maisonneuve-Rosemont Hospital Research Center, Montreal, Canada.
Biol Blood Marrow Transplant. 2012 Sep;18(9):1329-40. doi: 10.1016/j.bbmt.2012.01.020. Epub 2012 Feb 8.
Transforming growth factor (TGF)-β is a pleiotropic cytokine with widespread and profound effects on immune cells. Consequently, it has generated considerable interest in relation to the immunologic outcomes after allogeneic hematopoietic cell transplantation. The TGF-β pathway has been shown to be an important modulator of alloimmunity, with direct consequences on graft-versus-host disease pathophysiology and graft-versus-tumor response. The TGF-β-related effects can be both beneficial and detrimental to the host, underscoring the complexity of TGF-β biology. This article reviews the evidence linking TGF-β to alloimmune responses in allogeneic hematopoietic cell transplantation and highlights foreseeable strategies that would maximize the beneficial effects of TGF-β pathway modulation on both graft-versus-host disease pathophysiology and the graft-versus-tumor effect.
转化生长因子 (TGF)-β 是一种多功能细胞因子，对免疫细胞具有广泛而深刻的影响。因此，它在异基因造血细胞移植后的免疫结果方面引起了相当大的兴趣。TGF-β 途径已被证明是同种异体免疫的重要调节剂，对移植物抗宿主病的发病机制和移植物抗肿瘤反应有直接影响。TGF-β 相关的作用对宿主既有好处也有坏处，这突显了 TGF-β 生物学的复杂性。本文综述了 TGF-β 与异基因造血细胞移植中同种免疫反应的关系，并强调了预见的策略，这些策略将最大限度地提高 TGF-β 途径调节对移植物抗宿主病发病机制和移植物抗肿瘤效应的有益作用。
