贩运至核膜的未知领域。
Trafficking to uncharted territory of the nuclear envelope.
机构信息
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States.
出版信息
Curr Opin Cell Biol. 2012 Jun;24(3):341-9. doi: 10.1016/j.ceb.2012.01.009. Epub 2012 Feb 10.
Abstract
The nuclear envelope (NE) in eukaryotic cells serves as the physical barrier between the nucleus and cytoplasm. Until recently, mechanisms for establishing the composition of the inner nuclear membrane (INM) remained uncharted. Current findings uncover multiple pathways for trafficking of integral and peripheral INM proteins. A major route for INM protein transport occurs through the nuclear pore complexes (NPCs) with additional requirements for nuclear localization sequences, transport receptors, and Ran-GTP. Studies also reveal a putative NPC-independent vesicular pathway for NE trafficking. INM perturbations lead to changes in nuclear physiology highlighting the potential human disease impacts of continued NE discoveries.
摘要
真核细胞的核膜（NE）作为细胞核和细胞质之间的物理屏障。直到最近，内核膜（INM）组成的形成机制仍未被发现。目前的研究结果揭示了多种完整和周边 INM 蛋白的运输途径。INM 蛋白运输的主要途径是通过核孔复合物（NPCs），还需要核定位序列、运输受体和 Ran-GTP。研究还揭示了一种潜在的 NPC 独立的核膜运输小泡途径。INM 的扰动会导致核生理发生变化，突出了不断发现的 NE 对人类疾病的潜在影响。
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