Institute of Functional Material Chemistry, Faculty of Chemistry, Northeast Normal University, Changchun 130024, PR China.
Chemistry. 2012 Mar 19;18(12):3745-52. doi: 10.1002/chem.201103066. Epub 2012 Feb 10.
The selected-control preparation of uniform core-shell and yolk-shell architectures, which combine the multiple functions of a superparamagnetic iron oxide (SPIO) core and europium-doped yttrium oxide (Y(2)O(3):Eu) shell in a single material with tunable fluorescence and magnetic properties, has been successfully achieved by controlling the heat-treatment conditions. Furthermore, the shell thickness and interior cavity of SPIO@Y(2)O(3):Eu core-shell and yolk-shell nanostructures can be precisely tuned. Importantly, as-prepared SPIO@Y(2)O(3):Eu yolk-shell nanocapsules (NCs) modified with amino groups as cancer-cell fluorescence imaging agents are also demonstrated. To the best of our knowledge, this is the first report on the selected-control fabrication of uniform SPIO@Y(2)O(3):Eu core-shell nanoparticles and yolk-shell NCs. The combined magnetic manipulation and optical monitoring of magnetic-fluorescent SPIO@Y(2)O(3):Eu yolk-shell NCs will open up many exciting opportunities in dual imaging for targeted delivery and thermal therapy.
通过控制热处理条件，成功制备了具有均匀核壳和蛋黄壳结构的选择控制前体，将超顺磁氧化铁（SPIO）核和掺铕氧化钇（Y（2）O（3）：Eu）壳的多种功能结合在具有可调荧光和磁性能的单一材料中。此外，还可以精确调节 SPIO@Y（2）O（3）：Eu 核壳和蛋黄壳纳米结构的壳层厚度和内部空腔。重要的是，还展示了用氨基修饰的作为癌细胞荧光成像剂的 SPIO@Y（2）O（3）：Eu 蛋黄壳纳米胶囊（NCs）。据我们所知，这是首次报道通过选择控制制备均匀的 SPIO@Y（2）O（3）：Eu 核壳纳米粒子和蛋黄壳 NCs。磁荧光 SPIO@Y（2）O（3）：Eu 蛋黄壳 NCs 的联合磁操纵和光学监测将为靶向递药和热疗的双重成像开辟许多令人兴奋的机会。
