莱氏无胆甾原体细胞在培养老化过程中质膜内胆固醇的积累及膜酶活性的变化。
Cholesterol accumulation in plasma membrane and changes of membrane enzyme activity of Acholeplasma laidlawii cells during culture ageing.
作者信息
Kapitanov A B, Ivanova V F, Ladygina V G
机构信息
Laboratory of Cell Cultures, Scientific Research Institute of Phisico-chemical Medicine, Ministry of Health RSFSR, M. Pirogovskaya, Moscow, U.S.S.R.
出版信息
Mech Ageing Dev. 1990 Aug;55(2):161-9. doi: 10.1016/0047-6374(90)90023-9.
The data presented in this report show that the microviscosity of the plasma membrane and the cholesterol/phospholipid molar ratio of its lipid bilayer increases during ageing of Acholeplasma laidawii cultures. At the same time the age changes of other lipid components content do not correlate with the change of membrane viscosity. It is also shown that membrane enzyme activities of mycoplasma cell decrease with age. These results confirm the membrane hypothesis of ageing according to which increased microviscosity is the essential factor of cell ageing.
本报告中呈现的数据表明，在莱氏无胆甾原体培养物老化过程中，其质膜的微粘度及其脂质双层的胆固醇/磷脂摩尔比会增加。与此同时，其他脂质成分含量的年龄变化与膜粘度的变化不相关。研究还表明，支原体细胞膜酶活性会随着年龄增长而降低。这些结果证实了老化的膜假说，即微粘度增加是细胞老化的关键因素。
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