Telomeres & Cancer Laboratory, UMR3244, Institut Curie-CNRS-UPMC, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
Semin Cancer Biol. 2013 Apr;23(2):116-24. doi: 10.1016/j.semcancer.2012.02.001. Epub 2012 Feb 11.
Telomeres are crucial for the maintenance of genome stability through "capping" of chromosome ends to prevent their recognition as double-strand breaks, thus avoiding end-to-end fusions or illegitimate recombination [1-3]. Similar to other genomic regions, telomeres participate to the nuclear architecture while being highly mobile. The interaction of telomeres with nuclear domains or compartments greatly differs not only between organisms but also between cells within the same organism. It is also expected that biological processes like replication, repair or telomere elongation impact the distribution of chromosome extremities within the nucleus, as they probably do with other regions of the genome. Pathological processes such as cancer induce profound changes in the nuclear architecture, which also affects telomere dynamics and spatial organization. Here we will expose our present knowledge on the relationship between telomeres and nuclear architecture and on how this relationship is affected by normal or abnormal telomere metabolisms.
端粒对于维持基因组稳定性至关重要，通过“帽状”结构来保护染色体末端，防止其被识别为双链断裂，从而避免末端到末端的融合或非同源重组[1-3]。与其他基因组区域类似，端粒参与核结构，同时具有高度的移动性。端粒与核域或隔室的相互作用不仅在不同生物体之间存在差异，在同一生物体的不同细胞之间也存在差异。复制、修复或端粒伸长等生物学过程可能会影响染色体末端在核内的分布，就像它们影响基因组的其他区域一样。癌症等病理过程会引起核结构的深刻变化，这也会影响端粒的动态和空间组织。在这里，我们将介绍目前关于端粒与核结构之间关系的知识，以及正常或异常端粒代谢如何影响这种关系。
