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针对人工关节周围感染的治疗方法有哪些?一项多中心回顾性系列研究的结果。

What treatment for periprosthetic shoulder infection? Results from a multicentre retrospective series.

机构信息

Dipartimento di Chirurgia Ricostruttiva e delle InfezioniOsteo-articolari, Istituto Ortopedico I.R.C.C.S. Galeazzi, Via Riccardo Galeazzi, 4, Milano 20161, Italy.

出版信息

Int Orthop. 2012 May;36(5):1011-7. doi: 10.1007/s00264-011-1467-4. Epub 2012 Feb 14.

Abstract

PURPOSE

Controversy still exists as to the best surgical treatment for periprosthetic shoulder infections. The aim of this multi-institutional study was to review a continuous retrospectiveseries of patients treated in four European centres and to assess the respective eradication rate of various treatment approaches.

METHODS

Forty-four patients were available for this retrospective follow-up evaluation. Functional and clinical evaluation of treatment for infection was performed using the Constant-Murley score, visual analogue scale and patient satisfaction Neer score. Erythrocyte sedimentation rate, serum leucocyte count and C-reactive protein were measured and shoulder X-ray examination performed prior to surgery and at the latest follow-up.

RESULTS

At a mean follow-up of 41 months (range 24–98),42 of 44 patients (95.5%) showed no signs of infection recurrence/persistence. Comparable eradication rates were observed after resection arthroplasty (100%; 6/6), two-stage revision (17/17) or permanent antibiotic-loaded spacer implant (93.3%; 14/15). No patient was treated by one-stage revision. On average, both functional and pain scores improved significantly; the worst joint function was observed after resection arthroplasty.

CONCLUSIONS

This retrospective analysis conducted on the largest published series of patients to date shows comparable infection eradication rates after two-stage revision, resection arthroplasty or permanent spacer implant for the treatment of septic shoulder prosthesis.

摘要

目的

对于人工关节周围感染的最佳手术治疗方法仍存在争议。本多机构研究的目的是回顾在四个欧洲中心治疗的连续病例系列,并评估各种治疗方法的各自清除率。

方法

44 名患者可进行此回顾性随访评估。使用 Constant-Murley 评分、视觉模拟评分和患者满意度 Neer 评分对感染的治疗进行功能和临床评估。在手术前和随访时测量红细胞沉降率、血清白细胞计数和 C 反应蛋白,并进行肩部 X 射线检查。

结果

在平均 41 个月(范围 24-98)的随访中,44 例患者中有 42 例(95.5%)没有感染复发/持续的迹象。关节切除成形术(100%,6/6)、两阶段翻修(17/17)或永久性抗生素载药间隔器植入(93.3%,14/15)的清除率相当。没有患者接受一期翻修。平均而言,功能和疼痛评分均显著改善;关节功能最差见于关节切除成形术。

结论

这是迄今为止对最大的已发表患者系列进行的回顾性分析,表明在治疗感染性肩假体方面,两阶段翻修、关节切除成形术或永久性间隔器植入的感染清除率相当。

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