Meyburgh D, Malan L, Van Rooyen J M, Potgieter J C
School for Physiology, Nutrition and Consumer Sciences, North-West University, Potchefstroom, South Africa.
Cardiovasc J Afr. 2012 Feb;23(1):28-33. doi: 10.5830/CVJA-2010-101.
To assess the relationships between progression of target-organ damage and cardiovascular, cortisol and coping responses in black urban Africans.
Urban black African gender groups (n = 200) aged 21-62 years from the Sympathetic Activity and Ambulatory Blood Pressure in Africans study were stratified into normotensive and hypertensive groups. Resting and reactivity Finometer blood pressure, fasting sodium fluoride glucose and salivary cortisol values were obtained before and after applying the Stroop and cold pressor tests. Coping strategies were determined and high-resolution ultrasound carotid intima-media scans were done to determine progression of target-organ damage.
A trend of high-normal resting cortisol values during sampling time 1 was demonstrated in all hypertensive men. Both hypertensive gender groups showed increased vascular responses during both mental stressors. During the cold pressor test, vascular responses predicted sub-clinical atherosclerosis in all hypertensive men, independent of sampling time.
Early morning vascular responses in all the hypertensive men could have occurred secondarily to the permissive effect of cortisol on norepinephrine secretion, with subsequent α-adrenergic vasoconstriction. Their α-adrenergic vascular responses during the cold pressor test, however, predicted sub-clinical atherosclerosis, independent of sampling time and cortisol level.
评估非洲城市黑人中靶器官损害进展与心血管、皮质醇及应对反应之间的关系。
来自非洲人交感神经活动与动态血压研究的21至62岁城市非洲黑人性别组（n = 200）被分为正常血压组和高血压组。在进行Stroop测试和冷加压测试之前及之后，获取静息和反应性Finometer血压、空腹氟化钠葡萄糖及唾液皮质醇值。确定应对策略，并进行高分辨率超声颈动脉内膜中层扫描以确定靶器官损害的进展情况。
在所有高血压男性中，在采样时间1期间呈现出高正常静息皮质醇值的趋势。两个高血压性别组在两种精神应激源期间均显示血管反应增加。在冷加压测试期间，血管反应可预测所有高血压男性的亚临床动脉粥样硬化，与采样时间无关。
所有高血压男性的清晨血管反应可能继发于皮质醇对去甲肾上腺素分泌的允许作用，随后发生α-肾上腺素能血管收缩。然而，他们在冷加压测试期间的α-肾上腺素能血管反应可预测亚临床动脉粥样硬化，与采样时间和皮质醇水平无关。
