在造血过程中氧化酶和活性氧：重点关注巨核细胞。
Oxidases and reactive oxygen species during hematopoiesis: a focus on megakaryocytes.
机构信息
Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA.
出版信息
J Cell Physiol. 2012 Oct;227(10):3355-62. doi: 10.1002/jcp.24071.
Abstract
Reactive oxygen species (ROS), generated as a result of various reactions, control an array of cellular processes. The role of ROS during megakaryocyte (MK) development has been a subject of interest and research. The bone marrow niche is a site of MK differentiation and maturation. In this environment, a gradient of oxygen tension, from normoxia to hypoxia results in different levels of ROS, impacting cellular physiology. This article provides an overview of major sources of ROS, their implication in different signaling pathways, and their effect on cellular physiology, with a focus on megakaryopoiesis. The importance of ROS-generating oxidases in MK biology and pathology, including myelofibrosis, is also described.
摘要
活性氧（ROS）作为各种反应的结果产生，控制着一系列细胞过程。ROS 在巨核细胞（MK）发育过程中的作用一直是研究的热点。骨髓龛是 MK 分化和成熟的部位。在这个环境中，氧气张力从正常氧合到缺氧形成梯度，导致 ROS 水平不同，从而影响细胞生理。本文概述了 ROS 的主要来源，它们在不同信号通路中的作用，以及它们对细胞生理的影响，重点是巨核细胞生成。还描述了 ROS 生成氧化酶在 MK 生物学和病理学中的重要性，包括骨髓纤维化。
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