Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Cell Stem Cell. 2011 Oct 4;9(4):298-310. doi: 10.1016/j.stem.2011.09.010.
Tissue homeostasis over the life of an organism relies on both self-renewal and multipotent differentiation of stem cells. Hematopoietic stem cells (HSCs) reside in a hypoxic bone marrow environment, and their metabolic status is distinct from that of their differentiated progeny. HSCs generate energy mainly via anaerobic metabolism by maintaining a high rate of glycolysis. This metabolic balance promotes HSC maintenance by limiting the production of reactive oxygen species, but leaves HSCs susceptible to changes in redox status. In this review, we discuss the importance of oxygen homeostasis and energy metabolism for maintenance of HSC function and long-term self-renewal.
组织在生物体的一生中的稳态依赖于干细胞的自我更新和多能分化。造血干细胞 (HSCs) 存在于低氧的骨髓环境中，其代谢状态与分化后代不同。HSCs 通过维持高糖酵解率主要通过无氧代谢来产生能量。这种代谢平衡通过限制活性氧的产生来促进 HSC 的维持，但使 HSCs 容易受到氧化还原状态变化的影响。在这篇综述中，我们讨论了氧稳态和能量代谢对于维持 HSC 功能和长期自我更新的重要性。
