疟原虫在红细胞中的生存策略与宿主细胞多态性。
The survival strategies of malaria parasite in the red blood cell and host cell polymorphisms.
作者信息
Dhangadamajhi Gunanidhi, Kar Shantanu Kumar, Ranjit Manoranjan
机构信息
Regional Medical Research Centre, Indian Council of Medical Research, Chandrasekharpur, Bhubaneswar 751023, India.
出版信息
Malar Res Treat. 2010;2010:973094. doi: 10.4061/2010/973094. Epub 2010 Aug 19.
Parasite growth within the erythrocyte causes dramatic alterations of host cell which on one hand facilitates nutrients acquisition from extracellular environment and on other hand contributes to the symptoms of severe malaria. The current paper focuses on interactions between the Plasmodium parasite and its metabolically highly reduced host cell, the natural selection of numerous polymorphisms in the genes encoding hemoglobin and other erythrocyte proteins.
疟原虫在红细胞内的生长会引起宿主细胞的显著变化，一方面有利于从细胞外环境获取营养，另一方面导致严重疟疾的症状。本文聚焦于疟原虫与其代谢高度简化的宿主细胞之间的相互作用，以及编码血红蛋白和其他红细胞蛋白的基因中众多多态性的自然选择。
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