Piechota-Urbańska Magdalena, Berner-Strzelczyk Aneta
Katedra Farmacji Stosowanej, Zakład Farmacji Aptecznej, Uniwersytet Medyczny w Łodzi.
Polim Med. 2011;41(4):17-25.
An attempt was made to produce and test, according to the guidelines of Polish Pharmacopeia VIII, new prescriptions of hydrogels which could be applied in the treatment of skin diseases associated with hyperpigmentation. Hydrogel formulations containing a substance of skin-whitening activity (arbutin) and glycol plant extract was produced on Carbopol Ultrez 10 base. Two glycol plant extracts of confirmed beneficial effect on skin were selected: an extract of ginkgo leaves and of rosemary. For comparative purposes also preparations with arbutin were produced in which propylene glycol was introduced instead of glycol plant extracts. The assumption of the carried out study was to investigate physicochemical properties of model formulations, estimation of arbutin pharmaceutical availability from the suggested formulations and the assessment of the effect of glycol plant extract components on the process of arbutin diffusion from the produced hydrogel formulations. The formulation viscosity parameters were determined using cone-plate digital rheometer. Gravimetric method was applied to estimate the kinetics of volatile components from the preparations. Potentiometric method was used to measure pH. The rate of arbutin release through a semipermeable membrane to the acceptor fluid was tested in vitro. Spectrophotometric method was used for the determination of the quantity of the released therapeutic substance at defined time intervals. All the proposed formulations are viscoelastic systems having yield stress. There is a strict dependence between rheological properties characterizing the tested hydrogels and the quantity of the arbutin released from them. The process of arbutin release to the acceptor fluid through a semipermeable membrane was most effective from the formulation containing glycol extract of ginkgo (F1A+M).
根据波兰药典VIII的指导方针，尝试生产并测试可用于治疗与色素沉着相关皮肤病的新型水凝胶处方。在卡波姆Ultrez 10基质上制备了含有皮肤美白活性物质（熊果苷）和植物二醇提取物的水凝胶制剂。选择了两种已证实对皮肤有有益作用的植物二醇提取物：银杏叶提取物和迷迭香叶提取物。为了进行比较，还制备了用丙二醇代替植物二醇提取物的含熊果苷的制剂。所开展研究的假设是研究模型制剂的物理化学性质，评估所建议制剂中熊果苷的药物可利用性，以及评估植物二醇提取物成分对所生产水凝胶制剂中熊果苷扩散过程的影响。使用锥板数字流变仪测定制剂的粘度参数。采用重量法估算制剂中挥发性成分的动力学。用电位法测量pH值。体外测试了熊果苷通过半透膜向接受液的释放速率。采用分光光度法在规定的时间间隔测定释放的治疗物质的量。所有所提议的制剂都是具有屈服应力的粘弹性体系。表征所测试水凝胶的流变学性质与从中释放的熊果苷量之间存在严格的相关性。熊果苷通过半透膜向接受液的释放过程在含有银杏二醇提取物的制剂（F1A+M）中最为有效。
