Hommes M J, Romijn J A, Godfried M H, Schattenkerk J K, Buurman W A, Endert E, Sauerwein H P
Department of Endocrinology, University of Amsterdam, The Netherlands.
Metabolism. 1990 Nov;39(11):1186-90. doi: 10.1016/0026-0495(90)90092-q.
Even in the absence of anorexia and malabsorption, weight loss is frequently observed in patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC). To investigate whether increased resting energy expenditure (REE) might be responsible for this weight loss, indirect calorimetry was performed in 18 human immunodeficiency virus (HIV)-infected men free of clinically active opportunistic infections for at least 2 months. Patients with AIDS (n = 11) or ARC (n = 7) had 9% higher rates of REE when compared with 11 healthy volunteers (P less than .05) with similar food intake and of the same body composition. The results obtained from patients with AIDS or ARC were identical. As no differences were found between patients and controls in plasma concentrations of catecholamines, thyroid hormones, cortisol, or tumor necrosis factor, except for lower concentrations of norepinephrine in the patients (mean +/- SD, 233 +/- 111 v 367 +/- 125 ng/L, patients v controls, P less than .01), this hypermetabolism is not explained by higher levels of these catabolic hormones. The results indicate that even in the absence of acute concomitant infections, increased REE may contribute to the weight loss in patients with AIDS or ARC.
即使没有食欲减退和吸收不良的情况，获得性免疫缺陷综合征（AIDS）或AIDS相关综合征（ARC）患者也经常出现体重减轻。为了研究静息能量消耗（REE）增加是否可能是导致这种体重减轻的原因，对18名未发生临床活动性机会性感染至少2个月的人类免疫缺陷病毒（HIV）感染男性进行了间接测热法检测。与11名食物摄入量相似且身体组成相同的健康志愿者相比，AIDS患者（n = 11）或ARC患者（n = 7）的REE高出9%（P <.05）。从AIDS患者或ARC患者获得的结果是相同的。除了患者体内去甲肾上腺素浓度较低（平均值±标准差，患者为233±111 ng/L，对照组为367±125 ng/L，P <.01）外，患者与对照组在儿茶酚胺、甲状腺激素、皮质醇或肿瘤坏死因子的血浆浓度方面未发现差异，因此这种高代谢不能用这些分解代谢激素水平升高来解释。结果表明，即使没有急性并发感染，REE增加也可能导致AIDS或ARC患者体重减轻。
