[5,10-亚甲基四氢叶酸还原酶C677T基因多态性与急性淋巴细胞白血病风险的关联研究：一项Meta分析]

[Study on the association between 5,10-methylenetrahydrofolate reductase C677T polymorphism and acute lymphoblastic leukemia risk: a Meta-analysis].

作者信息

Li Xiao-lei, Yu Feng, Zhang Yong, Qiu Jin-chun, Liu Si-ting, Liao Qing-chuan

机构信息

Department of Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2011 Oct;32(10):1030-6.

PMID:22333090

Abstract

OBJECTIVE

To evaluate the association between polymorphism of 5,10-methylenetrahydrofolate reductase C677T and risk of acute lymphoblastic leukemia (ALL).

METHODS

Electronic search strategy was carried out among the databases from home and abroad to collect qualified research papers, according to the inclusion and exclusion criteria. Data on case-control studies on association between MTHFR C677T polymorphism and susceptibility to ALL were collected and analyzed by models of TT vs. CC + CT or TT vs. CC through Meta-analysis. Stratified analysis was carried out according to different age groups (children or adult).

RESULTS

In systematical analysis, the pooled odds ratios of MTHFR C677T genetype TT vs. CC + CT or TT vs. CC were 0.87 (0.69 - 1.09) and 0.82 (0.63 - 1.06) respectively; in children's group, the pooled odds ratios of MTHFR C677T genetype TT vs. CC + CT or TT vs. CC were 0.92 (0.79 - 1.08), 0.88 (0.75 - 1.05) while in adult group, the pooled odds ratios of MTHFR C677T genetype TT vs. CC + CT or TT vs. CC were 0.45 (0.26 - 0.77), and 0.41 (0.22 - 0.72) respectively.

CONCLUSION

The MTHFR gene 677T variant might not be associated with the risk of children's ALL but might be associated with a reduced risk on adult's ALL.

摘要

目的

评估5,10-亚甲基四氢叶酸还原酶C677T多态性与急性淋巴细胞白血病（ALL）风险之间的关联。

方法

根据纳入和排除标准，在国内外数据库中进行电子检索策略，以收集合格的研究论文。收集关于MTHFR C677T多态性与ALL易感性之间关联的病例对照研究数据，并通过Meta分析，采用TT与CC + CT或TT与CC的模型进行分析。根据不同年龄组（儿童或成人）进行分层分析。

结果

在系统分析中，MTHFR C677T基因型TT与CC + CT或TT与CC的合并比值比分别为0.87（0.69 - 1.09）和0.82（0.63 - 1.06）；在儿童组中，MTHFR C677T基因型TT与CC + CT或TT与CC的合并比值比分别为0.92（0.79 - 1.08）、0.88（0.75 - 1.05），而在成人组中，MTHFR C677T基因型TT与CC + CT或TT与CC的合并比值比分别为0.45（0.26 - 0.77）和0.41（0.22 - 0.72）。