[中国人群中瘦素受体Gln223Arg和Pro1019Pro基因多态性与肥胖关系的Meta分析]

[Meta-analysis on the relationship between leptin receptor Gln223Arg and Pro1019Pro gene polymorphism and obesity in the Chinese population].

作者信息

Yang Gan-ping, Peng Si-hua, Zuo Shuang-yan, Wang Yi-ren, Peng Xiao-ning, Zeng Xiao-min

机构信息

Department of Epidemiology and Health Statistics, Central South University, Changsha, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2011 Oct;32(10):1037-42.

PMID:22333091

Abstract

OBJECTIVE

To evaluate the associations between polymorphisms of LEPR Gln223Arg, LEPR Pro1019Pro and the risk on obesity.

METHODS

A computerized search on literature was carried out in Wanfang, CNKI, VIP databases and CBM, PubMed, EMBASE databases to collect articles published between 1979 and 2010 concerning the associations between polymorphisms of LEPR Gln223Arg and/or LEPR Pro1019Pro and risk of obesity in the Chinese population. Odds ratios (ORs) were used to assess the strength of the association, and 95% confidence intervals (CIs) to present the precision of the estimates. Meta-analysis was performed using the STATA statistical software.

RESULTS

Fifteen literature were collected for Meta-analysis by the uniform inclusion and exclusion criteria. There were 1096 obese patients and 949 controls for polymorphisms of LEPR Gln223Arg in 9 papers, together with 961 obese patients and 818 controls for polymorphisms of LEPR Pro1019Pro in 8 papers. Overall, there were significant associations between decreased risk of obesity and LEPR Gln223Arg polymorphisms (-668 A→G) (G versus A, OR = 0.66, 95%CI: 0.49 - 0.89; AG and GG versus AA, OR = 0.50, 95%CI: 0.32 - 0.77; respectively). There were significant associations between increased risk of obesity and LEPR Pro1019Pro polymorphisms (-3057 G→A) (A versus G, OR = 1.61, 95%CI: 1.15 - 2.26; AG and AA versus GG, OR = 1.50, 95%CI: 1.08 - 2.08; respectively).

CONCLUSION

Variant alleles at both LEPR-668 and LEPR-3057 were associated with obesity in the Chinese Han-dominated population.

摘要

目的

评估瘦素受体（LEPR）基因Gln223Arg、Pro1019Pro多态性与肥胖风险之间的关联。

方法

通过检索万方、中国知网、维普数据库及中国生物医学文献数据库，以及PubMed、EMBASE数据库，收集1979年至2010年间发表的有关LEPR基因Gln223Arg和/或Pro1019Pro多态性与中国人群肥胖风险关联的文章。采用比值比（OR）评估关联强度，95%置信区间（CI）表示估计精度。使用STATA统计软件进行Meta分析。

结果

按照统一的纳入和排除标准，共收集到15篇文献进行Meta分析。9篇文献中，LEPR基因Gln223Arg多态性的肥胖患者有1096例，对照有949例；8篇文献中，LEPR基因Pro1019Pro多态性的肥胖患者有961例，对照有818例。总体而言，LEPR基因Gln（-668 A→G）多态性与肥胖风险降低显著相关（G对A，OR = 0.66，95%CI：0.49 - 0.89；AG和GG对AA，OR = 0.50，95%CI：0.32 - 0.77）。LEPR基因Pro（-3057 G→A）多态性与肥胖风险增加显著相关（A对G，OR = 1.61，95%CI：1.15 - 2.26；AG和AA对GG，OR = 1.50，95%CI：1.08 - 2.08）。