Wang Cai-yan, Huang Zi-rong, Li Xiao-tian
Department of Family Planning, Obstetrics & Gynecology Hospital, Fudan University, Shanghai, China.
Zhonghua Yi Xue Za Zhi. 2011 Dec 6;91(45):3179-81.
To compare the different effects of taking different kinds and doses of estrogen and progestogen after medical abortion on reducing vaginal hemorrhage time.
A total of 188 women undergoing medical abortion were recruited and randomized into 3 groups: group A (n = 41) starting marvelon (30 µg ethinylestradiol and 150 µg desogestrel) on the day of abortion for 21 days; group B (n = 53) starting progynova 2 mg/d on the day of abortion for 21 days and taking depogesterone 10 mg/d on the last 5 days; and group C (n = 94) as control. The vaginal hemorrhage time, days to onset of next menses and the outcome of medical abortion were compared.
There was no significant difference in the duration of hemorrhage between groups A and C [(20 ± 13) vs (19 ± 11) d, P > 0.05]. But the duration of hemorrhage in group B was significantly shorter than that in group C [(14 ± 7) vs (19 ± 11) d, P < 0.01]. There was no significant difference in the amount of hemorrhage among 3 groups (P > 0.05). The time to onset of first menses was similar between groups A and B [(34 ± 13) vs (30 ± 7) d]. And both were significantly shorter than that in group C [(39 ± 11) d, P < 0.05]. There were 3 (7.32%) incomplete abortions in group A, 4 (7.55%) in group B and 12 (12.77%) in group C (P > 0.05).
The sequential therapy of estrogen and progestogen after medical abortion may effectively reduce the duration of hemorrhage. And the combined oral contraceptive pills fail to significantly alter the duration of hemorrhage after medical abortion. But both can promote menstrual recovery significantly.
比较药物流产后服用不同种类及剂量的雌激素和孕激素对缩短阴道出血时间的不同效果。
共纳入188例接受药物流产的妇女，随机分为3组：A组（n = 41）于流产当日开始服用妈富隆（炔雌醇30 µg和去氧孕烯150 µg），共21天；B组（n = 53）于流产当日开始服用补佳乐2 mg/d，共21天，并在最后5天加用醋酸甲羟孕酮10 mg/d；C组（n = 94）为对照组。比较各组阴道出血时间、下次月经来潮时间及药物流产结局。
A组和C组出血持续时间差异无统计学意义[（20 ± 13）天 vs （19 ± 11）天，P > 0.05]。但B组出血持续时间显著短于C组[（14 ± 7）天 vs （19 ± 11）天，P < 0.01]。3组出血量差异无统计学意义（P > 0.05）。A组和B组首次月经来潮时间相似[（34 ± 13）天 vs （30 ± 7）天]，且均显著短于C组[（39 ± 11）天，P < 0.05]。A组有3例（7.32%）不全流产，B组有4例（7.55%），C组有12例（12.77%）（P > 0.05）。
药物流产后序贯应用雌激素和孕激素可有效缩短出血时间。复方口服避孕药未能显著改变药物流产后的出血时间。但两者均可显著促进月经恢复。
