囊液 Amphiregulin 对胰腺囊肿的诊断准确性。
Diagnostic accuracy of cyst fluid amphiregulin in pancreatic cysts.
机构信息
Department of Medicine, Stanford University, Stanford, CA 94305, USA.
出版信息
BMC Gastroenterol. 2012 Feb 14;12:15. doi: 10.1186/1471-230X-12-15.
BACKGROUND
Accurate tests to diagnose adenocarcinoma and high-grade dysplasia among mucinous pancreatic cysts are clinically needed. This study evaluated the diagnostic utility of amphiregulin (AREG) as a pancreatic cyst fluid biomarker to differentiate non-mucinous, benign mucinous, and malignant mucinous cysts.
METHODS
A single-center retrospective study to evaluate AREG levels in pancreatic cyst fluid by ELISA from 33 patients with a histological gold standard was performed.
RESULTS
Among the cyst fluid samples, the median (IQR) AREG levels for non-mucinous (n = 6), benign mucinous (n = 15), and cancerous cysts (n = 15) were 85 pg/ml (47-168), 63 pg/ml (30-847), and 986 pg/ml (417-3160), respectively. A significant difference between benign mucinous and malignant mucinous cysts was observed (p = 0.025). AREG levels greater than 300 pg/ml possessed a diagnostic accuracy for cancer or high-grade dysplasia of 78% (sensitivity 83%, specificity 73%).
CONCLUSION
Cyst fluid AREG levels are significantly higher in cancerous and high-grade dysplastic cysts compared to benign mucinous cysts. Thus AREG exhibits potential clinical utility in the evaluation of pancreatic cysts.
背景
临床上需要准确的检测方法来诊断黏液性胰腺囊肿中的腺癌和高级别异型增生。本研究评估了 Amphiregulin（AREG）作为胰腺囊液生物标志物用于区分非黏液性、良性黏液性和恶性黏液性囊肿的诊断效用。
方法
对 33 例经组织学金标准证实的患者进行了一项单中心回顾性研究，通过 ELISA 检测胰腺囊液中的 AREG 水平。
结果
在囊液样本中，非黏液性（n = 6）、良性黏液性（n = 15）和癌性囊肿（n = 15）的 AREG 中位（IQR）水平分别为 85 pg/ml（47-168）、63 pg/ml（30-847）和 986 pg/ml（417-3160）。良性黏液性和恶性黏液性囊肿之间存在显著差异（p = 0.025）。AREG 水平大于 300 pg/ml 对癌症或高级别异型增生的诊断准确率为 78%（敏感性 83%，特异性 73%）。
结论
与良性黏液性囊肿相比，癌性和高级别异型增生性囊肿的囊液 AREG 水平显著升高。因此，AREG 在胰腺囊肿的评估中具有潜在的临床应用价值。
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