Guo Xiao-xiao, Tian Zhuang, Liu Yong-tai, Wang Qian, Li Meng-tao, Zeng Xiao-feng, Zhu Wen-ling, Fang Quan
Department of Cardiology & Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Zhonghua Yi Xue Za Zhi. 2011 Nov 1;91(40):2832-6.
To explore the immediate effects of inhaled aerosolized iloprost on right heart function in adult patients with pulmonary arterial hypertension (PAH).
A total of 30 PAH patients were recruited. Right heart catheterization and echocardiography were performed before and immediately after the inhalation of iloprost (20 µg).
After inhalation, the values of mean pulmonary artery pressure (PAPm) and pulmonary vascular resistances (PVR) decreased markedly (42.5 ± 9.6 to 34.4 ± 11.9 mm Hg, P < 0.001; 9.6 ± 5.7 Wood unit to 7.1 ± 4.8 Wood unit, P < 0.001). And the value of tricuspid annular systolic motion peak velocity (TASm) increased markedly [(10.7 ± 2.1) cm/s vs (11.9 ± 2.5) cm/s, P < 0.01]. The baseline level of TASm was higher in acute responders than non-responders [(12.0 ± 2.2) cm/s vs (10.1 ± 1.8) cm/s, P = 0.01] and TASm increased markedly after inhalation in non-responders [(10.1 ± 1.8) cm/s vs (11.6 ± 2.3) cm/s, P < 0.01].
The inhalation of iloprost decreases the levels of PAPm and PVR and improve right heart functions in adult PAH patients. For non-responders, right heart function is worse and more benefits may be achieved after the inhalation of iloprost.
探讨吸入雾化伊洛前列素对成年肺动脉高压（PAH）患者右心功能的即时影响。
共招募30例PAH患者。在吸入伊洛前列素（20μg）之前及之后立即进行右心导管检查和超声心动图检查。
吸入后，平均肺动脉压（PAPm）和肺血管阻力（PVR）值显著降低（42.5±9.6至34.4±11.9mmHg，P<0.001；9.6±5.7伍德单位至7.1±4.8伍德单位，P<0.001）。三尖瓣环收缩期运动峰值速度（TASm）值显著升高[（10.7±2.1）cm/s对（11.9±2.5）cm/s，P<0.01]。急性反应者的TASm基线水平高于无反应者[（12.0±2.2）cm/s对（10.1±1.8）cm/s，P=0.01]，无反应者吸入后TASm显著升高[（10.1±1.8）cm/s对（11.6±2.3）cm/s，P<0.01]。
吸入伊洛前列素可降低成年PAH患者的PAPm和PVR水平并改善右心功能。对于无反应者，右心功能较差，吸入伊洛前列素后可能获得更多益处。
