Jin Hei-ying, Xu Jun-hua, Wang Xiao-feng, Ding Yi-jiang
Nanjing University of Traditional Chinese Medicine, Jiangsu Integrated Colorectal Oncology Center, Nanjing, China.
Zhonghua Yi Xue Za Zhi. 2011 Nov 8;91(41):2891-4.
To explore the roles of hairy enhancer of split 1 (Hes1) gene in colorectal cancer and analyze its clinical significance.
A total of 146 cases with colorectal cancer at our hospital were collected prospectively and followed up. There were 84 males and 62 females with an average age of (61 ± 11) years old. Tissue microarray was prepared and the expression of Notch signal genes were detected by immunohistochemical staining.
The differential expressions of Hes1 were significant among various types [negative or weakly positive: 8% (12/146), positive(+): 77% (112/146), positive(++): 15% (22/146)]. Among all, 134 were followed up successfully for an average duration of (42 ± 13) months. According to the Kaplan-Meier life curve, the overall 1, 3 and 5-year survival rates were 93% (136/146), 74% (108/146) and 67% (98/146) respectively. The long-term survival rate was correlated with TNM stage and pathological types (all P = 0.000), but not with Hes1 (P = 0.267).
The expression of Hes1 is correlated with pathological types and differentiation types. However the long-term survival rate is not correlated with its expression.
探讨分裂增强子1（Hes1）基因在结直肠癌中的作用，并分析其临床意义。
前瞻性收集我院146例结直肠癌患者资料并进行随访。其中男性84例，女性62例，平均年龄（61±11）岁。制备组织芯片，采用免疫组化染色检测Notch信号基因的表达。
Hes1在不同类型中的表达差异有统计学意义[阴性或弱阳性：8%（12/146），阳性（+）：77%（112/146），阳性（++）：15%（22/146）]。其中134例获得成功随访，平均随访时间（42±13）个月。根据Kaplan-Meier生存曲线，1、3、5年总生存率分别为93%（136/146）、74%（108/146）和67%（98/146）。长期生存率与TNM分期和病理类型有关（均P=0.000），但与Hes1无关（P=0.267）。
Hes1的表达与病理类型和分化类型有关，但其表达与长期生存率无关。
