Shen Xin-hua, Qian Min-cai, Niu Fu-rong, Sun Song-tao, Zhu Yi-ping, Yang Jian-hong, Lin Min, Yu Bo-run, Li Liang, Shen Zhong-xia
Department of Neurosis & Psychosomatic Diseases, Third Huzhou Hospital, Huzhou, China.
Zhonghua Yi Xue Za Zhi. 2011 Nov 8;91(41):2939-41.
To examine the changing pattern of brain-derived neurotrophic factor (BDNF) in the patients with first-episode generalized anxiety disorder (GAD).
The levels of plasma BDNF and the Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) scores were measured in 34 patients with first-episode GAD recruited from our hospital between January and December 2007. At baseline and Week 6, they were treated by paroxetine and compared with 31 healthy participants in the control group.
The baseline level of BDNF [(80 ± 51) ng/L] in the patients with first-episode GAD was higher than that in the control group and had no significant correlation with HAMA and HAMD scores. But at Week 6, the level of BDNF [(70 ± 49) ng/L] had significant correlations with HAMA and HAMD scores (r = 0.4, P = 0 and r = 0.4, P = 0 respectively). At Week 6, the levels of BDNF in the response group (including remission group) and ineffective group were (60 ± 42) ng/L and (83 ± 55) ng/L respectively. And there was significant difference in the levels of BDNF between the ineffective and control groups. The levels of BDNF in the remission and non-remission groups were (59 ± 52) ng/L and (73 ± 49) ng/L respectively. And there was significant difference in the levels of BDNF between the non-remission and control groups.
The pre-treatment levels of plasma BDNF in the patients with first-episode GAD are higher than those of healthy counterparts. But normal levels may be restored if the patients are cured.
探讨首发广泛性焦虑障碍（GAD）患者脑源性神经营养因子（BDNF）的变化模式。
对2007年1月至12月我院收治的34例首发GAD患者测定血浆BDNF水平、汉密尔顿焦虑量表（HAMA）及汉密尔顿抑郁量表（HAMD）评分。在基线期和第6周时，给予帕罗西汀治疗，并与31名健康对照组参与者进行比较。
首发GAD患者的BDNF基线水平[（80±51）ng/L]高于对照组，且与HAMA和HAMD评分无显著相关性。但在第6周时，BDNF水平[（70±49）ng/L]与HAMA和HAMD评分有显著相关性（r分别为0.4，P=0；r为0.4，P=0）。第6周时，有效组（包括缓解组）和无效组的BDNF水平分别为（60±42）ng/L和（83±55）ng/L。无效组与对照组的BDNF水平有显著差异。缓解组和未缓解组的BDNF水平分别为（59±52）ng/L和（73±49）ng/L。未缓解组与对照组的BDNF水平有显著差异。
首发GAD患者治疗前血浆BDNF水平高于健康对照者。但如果患者治愈，其水平可能恢复正常。
