Fan Wei-jun, Wang Li-gang, Zheng Yan-bo, Zhang Liang, Tang Tian, Li Xin, Jiang Hua, Zhang Jian-lei
Department of Imaging and Interventional Radiology, Sun Yat-sen University, Guangzhou, China.
Zhonghua Yi Xue Za Zhi. 2011 Nov 8;91(41):2942-6.
To elucidate the difference in both in vivo and ex vivo microwave ablation in a biliary cirrhotic porcine liver model using a cooled-tip antenna.
Two months after biliary ductal ligation, liver biopsy was performed to confirm the establishment of biliary cirrhosis in 4 Tibetan miniature pigs. Microwave ablation with cooled-tip antenna was conducted under laparotomy using 70 W for five minutes in the experimental group (4 pigs). The control group (2 pigs) also received microwave ablation using the same settings but no surgery. Both in-vivo and ex-vivo ablations were performed in the two groups. Morphological and pathological characteristics of the ablation areas were compared. Paired comparison among the groups were conducted using t-test.
In the cirrhotic liver group, after ablation at 70 W for five minutes, the short and long axes and volume of in vivo ablation areas were (1.90 ± 0.10) cm, (2.95 ± 0.12) cm, and (6.0 ± 0.8) cm(3) compared to (2.08 ± 0.08) cm, (3.08 ± 0.75) cm, and (7.0 ± 0.5) cm(3) of ex vivo ablation. In the normal liver group the dates were (2.04 ± 0.05) cm, (3.14 ± 0.11) cm and (6.8 ± 0.5) cm(3); (2.30 ± 0.18) cm, (3.60 ± 0.08) cm and (10.0 ± 1.7) cm(3), respectively. In vivo ablation area was smaller than ex vivo ablation area in terms of short and long axes and volume (P = 0.028 0.026, 0.008, respectively). With the same ablation settings, both in vivo and ex vivo ablation areas in normal pig liver were larger than their counterparts in cirrhotic liver in terms of the short and long axes and volume (P = 0.019, P = 0.000; P = 0.024, P = 0.036, respectively), but the differences in the short axes of in vivo and ex vivo ablation areas failed to reach significance.
Both in vivo and ex vivo ablation areas in biliary cirrhotic pig liver were smaller than their counterparts in normal pig liver suggesting that, the ablation time or power should be relatively prolonged to enlarge the ablation zone within cirrhotic liver in order to prevent incomplete ablation with viable residual tumor.
使用冷循环微波天线阐明在胆管性肝硬化猪肝脏模型中体内和体外微波消融的差异。
在胆管结扎两个月后，对4只西藏小型猪进行肝脏活检以确认胆管性肝硬化的形成。实验组（4只猪）在剖腹手术下使用冷循环微波天线以70W功率进行5分钟的微波消融。对照组（2只猪）也使用相同设置进行微波消融，但不进行手术。两组均进行体内和体外消融。比较消融区域的形态学和病理学特征。组间配对比较采用t检验。
在肝硬化肝脏组中，以70W功率消融5分钟后，体内消融区域的短轴、长轴和体积分别为（1.90±0.10）cm、（2.95±0.12）cm和（6.0±0.8）cm³，而体外消融分别为（2.08±0.08）cm、（3.08±0.75）cm和（7.0±0.5）cm³。在正常肝脏组中，相应数据分别为（2.04±0.05）cm、（3.14±0.11）cm和（6.8±0.5）cm³；（2.30±0.18）cm、（3.60±0.08）cm和（10.0±1.7）cm³。在短轴、长轴和体积方面，体内消融区域均小于体外消融区域（P分别为0.028、0.026、0.008）。在相同消融设置下，正常猪肝的体内和体外消融区域在短轴、长轴和体积方面均大于肝硬化猪肝的相应区域（P分别为0.019、P = 0.000；P分别为0.024、0.036），但体内和体外消融区域短轴的差异未达到显著水平。
胆管性肝硬化猪肝的体内和体外消融区域均小于正常猪肝的相应区域，这表明在肝硬化肝脏中应相对延长消融时间或提高功率以扩大消融范围，从而防止残留有活性肿瘤组织导致消融不完全。
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