微波消融与内置冷循环探针的双极射频消融的比较：离体和活体猪肝脏的结果。
A comparison of microwave ablation and bipolar radiofrequency ablation both with an internally cooled probe: results in ex vivo and in vivo porcine livers.
机构信息
Department of Interventional Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.
出版信息
Eur J Radiol. 2011 Jul;79(1):124-30. doi: 10.1016/j.ejrad.2009.12.009. Epub 2010 Jan 4.
PURPOSE
The purpose of this study was to compare the effectiveness of microwave (MW) ablation and radiofrequency (RF) ablation using a single internally cooled probe in a hepatic porcine model.
MATERIALS AND METHODS
In the ex vivo experiment, MW ablations (n=40) were performed with a 2450MHz and 915MHz needle antenna, respectively at 60W, 70W power settings. Bipolar RF ablations (n=20) were performed with a 3-cm (T30) and 4-cm (T40) active tip needle electrodes, respectively at a rated power 30W and 40W according to automatically systematic power setting. In the in vivo experiment, the 2450 MHz and 915 MHz MW ablation both at 60W and T30 bipolar RF ablation at 30 W were performed (n=30). All of the application time were 10 min. Long-axis diameter (Dl), short-axis diameter (Ds), ratio of Ds/Dl, the temperature data 5mm from the needle and the time of temperature 5mm from the needle rising to 54°C were measured.
RESULTS
Both in ex vivo and in vivo models, Ds and Dl of 915 MHz MW ablations were significantly larger than all the RF ablations (P<0.05); the Ds for all the 2450MHz MW ablations were significantly larger than that of T30 RF ablations (P<0.05). 2450MHz MW and T30 RF ablation tended to produce more elliptical-shaped ablation zone. Tissue temperatures 5mm from the needle were considerably higher with MW ablation, meanwhile MW ablation achieved significantly faster rate of temperature rising to 54°C than RF ablation. For in vivo study after 10 min of ablation, the Ds and Dl of 2450 MHz MW, 915 MHz MW and Bipolar RF were 2.35±0.75, 2.95±0.32, 1.61±0.33 and 3.86±0.81, 5.79±1.03, 3.21±0.51, respectively. Highest tissue temperatures 5mm from the needle were 80.07±12.82°C, 89.07±3.52°C and 65.56±15.31°C and the time of temperature rising to 54°C were respectively 37.50±7.62s, 24.50±4.09s and 57.29±23.24s for three applicators.
CONCLUSION
MW ablation may have higher potential for complete destruction of liver tumors than RF ablation.
目的
本研究旨在比较微波（MW）消融和使用单根内部冷却探针的射频（RF）消融在猪肝模型中的效果。
材料与方法
在离体实验中，分别使用 2450MHz 和 915MHz 针状天线在 60W、70W 功率设置下进行 MW 消融（n=40）。双极 RF 消融（n=20）分别使用 3cm（T30）和 4cm（T40）活性尖端针电极，在自动系统功率设置下分别以额定功率 30W 和 40W 进行。在体内实验中，对 2450MHz 和 915MHz 的 MW 消融（n=30），两者均为 60W 和 T30 双极 RF 消融（n=30），功率均为 30W。所有应用时间均为 10min。测量距针 5mm 处的长轴直径（Dl）、短轴直径（Ds）、Ds/Dl 比值、距针 5mm 处的温度数据以及距针 5mm 处的温度上升至 54°C 的时间。
结果
在离体和体内模型中，915MHz MW 消融的 Ds 和 Dl 均显著大于所有 RF 消融（P<0.05）；所有 2450MHz MW 消融的 Ds 均显著大于 T30 RF 消融（P<0.05）。2450MHz MW 和 T30 RF 消融倾向于产生更椭圆形的消融区。距针 5mm 处的组织温度在 MW 消融时明显较高，同时 MW 消融达到 54°C 的升温速度明显快于 RF 消融。在体内研究中，10min 消融后，2450MHz MW、915MHz MW 和双极 RF 的 Ds 和 Dl 分别为 2.35±0.75、2.95±0.32、1.61±0.33 和 3.86±0.81、5.79±1.03、3.21±0.51。距针 5mm 处的最高组织温度分别为 80.07±12.82°C、89.07±3.52°C 和 65.56±15.31°C，温度上升至 54°C 的时间分别为 37.50±7.62s、24.50±4.09s 和 57.29±23.24s。
结论
MW 消融在完全破坏肝肿瘤方面可能比 RF 消融具有更高的潜力。
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