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[基于肿瘤生育力治疗实践探讨年轻癌症患者生育力保存的可能性]

[The possibility of the fertility preservation in young cancer patients based on practice of oncofertility treatment].

作者信息

Suzuki Nao, Yoshioka Nobuhito, Sugishita Yodo, Takae Seido, Horage Yuki, Igarashi Suguru, Hashimoto Shu, Morimoto Yoshiharu, Ishizuka Bunpei

机构信息

Dept. of Obstetrics and Gynecology, St. Marianna University School of Medicine, Japan.

出版信息

Gan To Kagaku Ryoho. 2012 Feb;39(2):151-7.

Abstract

Young female cancer patients face various problems, including a decrease in their quality of life(QOL)due to early menopause or loss of fertility after remission. Chemotherapy and radiotherapy can cause loss of reproductive function in young women due to adverse effects such as ovarian failure. The frequency of ovarian failure depends on the age of the patient, the anticancer agents used, and the dose of each agent. In these patients, improvement of the post-treatment QOL and fertility preservation can be achieved by measures such as protection of ovarian function against the effects of anticancer agents. Ovum freezing or fertilized egg freezing are also becoming fertility preservation methods for these patients. However, ovarian hyperstimulation to obtain ova is time consuming and sometimes considered taboo depending on the type of cancer. A self solution to problems occurring frequently at the same time is demanded from the patient, and the patient is forced to deal with too many choices in too little time. It is often less than one month until the cancer treatment begins after an underlying disease is diagnosed, since chemotherapy cannot be delayed. In these cases, cryopreservation of ovarian tissue is currently proposed for fertility preservation. In this manuscript, I will discuss a topic about fertility preservation in young cancer survivors including recent knowledge regarding cryopreservation of ovarian tissue.

摘要

年轻女性癌症患者面临各种问题,包括因早期绝经或缓解后生育能力丧失导致生活质量(QOL)下降。化疗和放疗可能因卵巢衰竭等不良反应导致年轻女性生殖功能丧失。卵巢衰竭的发生率取决于患者年龄、所用抗癌药物以及每种药物的剂量。在这些患者中,通过保护卵巢功能免受抗癌药物影响等措施,可以实现治疗后生活质量的改善和生育力保存。卵子冷冻或受精卵冷冻也正成为这些患者的生育力保存方法。然而,通过卵巢过度刺激获取卵子耗时,且有时根据癌症类型被视为禁忌。患者需要自行解决同时频繁出现的问题,并且被迫在极短时间内应对过多选择。自潜在疾病被诊断后,往往不到一个月癌症治疗就开始了,因为化疗不能延迟。在这些情况下,目前建议通过冷冻保存卵巢组织来保存生育力。在本手稿中,我将讨论年轻癌症幸存者生育力保存的相关话题,包括卵巢组织冷冻保存的最新知识。

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