Kern Karl B
Sarver Heart Center, University of Arizona, Tucson, Arizona 85724, USA.
Curr Opin Crit Care. 2012 Jun;18(3):246-50. doi: 10.1097/MCC.0b013e32835180d6.
The role of cardiac arrest centers, more recently termed Cardiac Receiving Centers, in improving outcomes after successful resuscitation is becoming more and more convincing. But which of all the treatments provided by Cardiac Receiving Centers are most beneficial is less certain. This review examines the role of early coronary angiography and percutaneous coronary intervention in this regard.
Cohort studies have consistently found that early coronary angiography is associated with improved long-term outcomes postcardiac arrest. The most common cause for out-of-hospital cardiac arrest is a myocardial ischemic event. Diagnosing and treating the underlying coronary trigger makes good physiological sense. The major issues are 'who' should undergo emergent coronary angiography and 'when' should it be done. Standard criteria such as ST segment elevation and precedent chest pains are not very sensitive in identifying those postcardiac arrest with an occluded or culprit lesion. As many as one in four postresuscitated patients without ST elevation have a significant culprit lesion, including at times an acutely occluded coronary. Cardiac Receiving Centers should have the capacity to perform emergent coronary angiography on every resuscitated patient who does not have an obvious noncardiac cause for their arrest.
Emergent coronary angiography and percutaneous coronary intervention are the most important Cardiac Receiving Center treatments beyond hypothermia. Providing both of these essential postresuscitation therapies is the very purpose of such centers.
心脏骤停中心,最近更名为心脏接收中心,在成功复苏后改善预后方面的作用越来越令人信服。但心脏接收中心提供的所有治疗中,哪一种最有益尚不确定。本综述探讨早期冠状动脉造影和经皮冠状动脉介入治疗在这方面的作用。
队列研究一致发现,早期冠状动脉造影与心脏骤停后改善长期预后相关。院外心脏骤停最常见的原因是心肌缺血事件。诊断和治疗潜在的冠状动脉触发因素具有良好的生理意义。主要问题是“谁”应接受紧急冠状动脉造影以及“何时”进行造影。诸如ST段抬高和既往胸痛等标准在识别心脏骤停后有闭塞或罪犯病变的患者时并不十分敏感。多达四分之一无ST段抬高的复苏后患者有明显的罪犯病变,有时包括急性闭塞的冠状动脉。心脏接收中心应具备对每一位无明显非心脏原因导致心脏骤停的复苏患者进行紧急冠状动脉造影的能力。
紧急冠状动脉造影和经皮冠状动脉介入治疗是除低温治疗外心脏接收中心最重要的治疗方法。提供这两种重要的复苏后治疗正是此类中心的宗旨。