Medical Faculty, Masaryk University, Kamenice 5, Brno, Czech Republic.
Nutr Neurosci. 2012 Jul;15(4):163-70. doi: 10.1179/1476830512Y.0000000001. Epub 2012 Feb 2.
The endocannabinoid receptor 1 (CB1) is encoded by the CNR1 gene and has been recently recognized to play an important role in the regulation of satiety and feeding behaviour with a huge potential of modulating metabolic response and feeding control. The aim of the study was to investigate the potential of three selected single nucleotide polymorphisms (SNPs) in the CNR1 locus on native dietary composition in the Central-European Caucasian population.
A total of 258 unrelated individuals originating from the Central-European Caucasian population were enrolled into the study and rs1049353, rs12720071, and rs806368 polymorphisms in CNR1 locus were examined in these individuals using PCR-based methodology. Body composition was assessed using a bioimpedance method, various anthropometric parameters were investigated (waist and hip circumference, skin folds), and native dietary composition was analysed using 7-day food records as well as a food frequency questionnaire.
Allelic variations and common haplotypes in the CNR1 gene were associated with the daily intake of proteins, fluids, and fibre, regardless of the physical activity of the individuals. The common haplotype in the CNR1 gene was associated with self-reported smoking (number of cigarettes per day, smoking years).
Our results indicate that specific genetic variations in the CNR1 gene may act as susceptibility markers for specific dietary composition in the Central-European population.
内源性大麻素受体 1（CB1）由 CNR1 基因编码，最近被认为在调节饱腹感和进食行为方面发挥着重要作用，具有调节代谢反应和进食控制的巨大潜力。本研究旨在探讨中欧高加索人群中 CNR1 基因座上三个选定的单核苷酸多态性（SNP）对天然饮食成分的潜在影响。
本研究共纳入 258 名来自中欧高加索人群的无关个体，使用基于 PCR 的方法检测 CNR1 基因座上的 rs1049353、rs12720071 和 rs806368 多态性。使用生物阻抗法评估身体成分，研究各种人体测量参数（腰围和臀围、皮褶），并使用 7 天食物记录和食物频率问卷分析天然饮食成分。
CNR1 基因的等位基因变异和常见单倍型与个体的体力活动无关，与蛋白质、液体和纤维的日摄入量有关。CNR1 基因的常见单倍型与自我报告的吸烟（每天吸烟的数量、吸烟年限）有关。
我们的结果表明，CNR1 基因中的特定遗传变异可能是中欧人群特定饮食成分的易感标志物。
