Stambolis C
Zentralbl Allg Pathol. 1979;123(1-2):3-8.
In nephrectomy specimens from a series of 24 Wilms' tumors three different types of neoplastic lesion were found in the uninvolved kidney parenchyma: nodular renal blastema, Wilms' tumorlet and metanephric hamartomas. The histologic features of the first two abnormalities are presented. They show the following characteristics: Being found in patients of younger age they occur mostly bilateral. In older children they are associated to Wilms' tumor. They are related, as this is the case with Wilms' tumors, to certain congenital malformation syndromes. Nodular blastema has been also observed in association with Wilms' tumor in siblings. These findings suggest a genetic relationship between nodular renal blastema-nephroblastomatosis complex and Wilms' tumor. Furthermore, such lesions may represent potential progenitor stages of most nephroblastomas. The clinical implications hereof are discussed.
在一系列24例肾母细胞瘤的肾切除标本中，在未受累的肾实质内发现了三种不同类型的肿瘤性病变：结节性肾胚基、肾母细胞瘤小结和后肾错构瘤。本文介绍了前两种异常的组织学特征。它们具有以下特点：多见于较年轻患者，多为双侧发生。在大龄儿童中，它们与肾母细胞瘤相关。与肾母细胞瘤一样，它们与某些先天性畸形综合征有关。在同胞的肾母细胞瘤中也观察到结节性胚基与肾母细胞瘤相关。这些发现提示结节性肾胚基-肾母细胞瘤病复合体与肾母细胞瘤之间存在遗传关系。此外，此类病变可能代表大多数肾母细胞瘤的潜在祖细胞阶段。本文讨论了其临床意义。
