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[儿童期肾母细胞瘤可切除性的评估]

[Assessment of the resectability of Wilms' tumors in childhood].

作者信息

Schaarschmidt K, Ritter J, Willital G H, Olesczcuk-Raschke K, Kindhäuser V, Stratmann U

机构信息

Klinik für Kinderchirurgie, Westfälische Wilhelms-Universität, Münster.

出版信息

Langenbecks Arch Chir Suppl Kongressbd. 1996;113:1084-90.

PMID:9101787
Abstract

Over the last ten years 62 children were operated for renal tumours. The therapeutic aim in Wilms' tumours is complete macroscopic resection of the primary tumour, assessing resectability as accurately as possible. Overestimating surgical possibilities may lead to intraoperative rupture of the tumour (three cases), while overestimating local tumour extent may result in too much preoperative chemotherapy, which resulted in the life-threatening complication of venous occlusive disease of the hepatic veins (VOD) in three infants. The assessment of resectability may become particularly problematic in bilateral (six cases) or multifocal Wilms' tumours (two cases), and in nephroblastomatosis (two cases), i.e. the persistence of embronal renal tissue, a facultatively precancerous lesion, which requires quarterly sonographic controls and which induced a second metachronous contralateral Wilms' tumour in one child.

摘要

在过去十年中,62名儿童接受了肾肿瘤手术。威尔姆斯瘤的治疗目标是对原发性肿瘤进行完整的肉眼切除,尽可能准确地评估可切除性。高估手术可能性可能导致肿瘤术中破裂(3例),而高估局部肿瘤范围可能导致术前化疗过度,这在3名婴儿中导致了危及生命的肝静脉闭塞性疾病(VOD)并发症。在双侧(6例)或多灶性威尔姆斯瘤(2例)以及肾母细胞瘤病(2例)中,可切除性的评估可能会特别困难。肾母细胞瘤病即胚胎性肾组织持续存在,这是一种潜在的癌前病变,需要每季度进行超声检查,并且在一名儿童中引发了第二例异时性对侧威尔姆斯瘤。

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