类风湿关节炎患者肺功能与疾病活动度的相关性
Correlation of lung function with disease activity rheumatoid arthritis.
作者信息
Al-Assadi Tarik, Al-Shemery Adnan, Salman Sami
出版信息
Oman Med J. 2009 Apr;24(2):84-8. doi: 10.5001/omj.2009.20.
OBJECTIVES
To find a correlation between Lung function with the disease activity in Rheumatoid arthritis (RA).
METHODS
The study was carried out on 40 (35 female and 5 male) patients with active RA who fulfilled the ARA 1987 reversed criteria for the classification of RA. Patients with signs and symptoms of respiratory disease or chest injury were excluded from this study. The patients were all examined clinically by weighted and selective index for active synovitis and assessed for functional status of the follwing; ESR, Hb % level, pulmonary function tests including FEV1, VC, FEV,/ FVC and DL(CO). Another group of 30 (27 female and 3 male) patients with active RA served as a control group.
RESULTS
The results showed that Hb level ranged between (7-13.3 gm/dl), ESR ranged between 11-131 mm/hr and restrictive ventilatory defect was observed in 15 (37.5%) patients. Obstructive ventilator defect was presented in 10 (25%) patients. A decreased in DLCO was detected in 23 (51.5%) patients. There was a positive correlation between PETS with Hb%, ESR, Disease duration and activity of synovitis (P<0.005).
CONCLUSION
Lung function can be used to stratify abnormalities in a clinically useful manner and can be used as an indicator of disease activity in RA.
目的
寻找类风湿关节炎（RA）患者肺功能与疾病活动度之间的相关性。
方法
对40例（35例女性和5例男性）符合1987年美国风湿病学会（ARA）类风湿关节炎分类修订标准的活动期RA患者进行研究。排除有呼吸系统疾病体征和症状或胸部损伤的患者。对所有患者进行临床检查，采用加权和选择性指数评估活动性滑膜炎，并评估以下功能状态；红细胞沉降率（ESR）、血红蛋白（Hb）水平、肺功能测试，包括第一秒用力呼气容积（FEV1）、肺活量（VC）、FEV1/FVC和一氧化碳弥散量（DL(CO)）。另一组30例（27例女性和3例男性）活动期RA患者作为对照组。
结果
结果显示，Hb水平在（7 - 13.3克/分升）之间，ESR在11 - 131毫米/小时之间，15例（37.5%）患者观察到限制性通气功能障碍。10例（25%）患者出现阻塞性通气功能障碍。23例（51.5%）患者检测到DLCO降低。PETS与Hb%、ESR、疾病持续时间和滑膜炎活动度之间存在正相关（P<0.005）。
结论
肺功能可用于以临床有用的方式对异常情况进行分层，并可作为RA疾病活动度的指标。
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