Kozak Irena, Dwilewicz-Trojaczek Jadwiga, Siemińska Jolanta, Górska Renata
1Zakład Chorób Błony Sluzowej i Przyzebia IS, WUM, Warszawa.
Wiad Lek. 2011;64(3):164-9.
Graft-versus-host disease (GVHD) is the most common and most serious complication of allogeneic hematopoetic stem cell transplantation (HSCT). The aim of this study was to assess the incidence of GVHD after allogeneic HSCT depending on the diagnosis and risk factors.
The study group comprised 78 patients aged 18 to 61 in whom allogeneic transplantation of hematopoietic stem cell in the Department and Clinic of Hematology, Oncology and Internal Diseases of Medical University in Warsaw (Poland) was performed.
Acute form of GVHD was significantly more often occurred after total body irradiation (TBI) for patients with TBI who did not (p < 0.05).
Risk factors for aGVHD were: age of the recipient, acute myeloid leukemia, myeloablative conditioning, TBI and unrelated donor.
移植物抗宿主病（GVHD）是异基因造血干细胞移植（HSCT）最常见且最严重的并发症。本研究旨在根据诊断和危险因素评估异基因HSCT后GVHD的发生率。
研究组包括78例年龄在18至61岁之间的患者，他们在华沙（波兰）医科大学血液学、肿瘤学和内科系及诊所接受了造血干细胞的异基因移植。
接受全身照射（TBI）的患者中，急性GVHD的发生率明显更高（未接受TBI的患者与之相比，p < 0.05）。
急性移植物抗宿主病的危险因素包括：受者年龄、急性髓系白血病、清髓性预处理、全身照射和无关供者。
