矽肺患者血清转化生长因子-β1和肿瘤坏死因子-α的变化

[Change of serum TGF-beta1 and TNF-alpha in silicosis patients].

作者信息

Miao Rong-Ming, Zhang Xue-Tao, Yan Yu-Lan, He En-Qi, Guo Ping, Zhang Ying-Yi, Zhao Dao-Kun, Yang Zhi-Gang, Chen Jie, Yao Ming-Ying, Zhao Rui, Fang Zhong-Hua, Yao Yong-Ming

机构信息

Wuxi Hospital for Prevention and Treatment of Occupational Disease, Wuxi, China.

出版信息

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2011 Aug;29(8):606-7.

PMID:22335161

Abstract

OBJECTIVE

To observe serum TGF-beta1 and TNF-alpha in silicosis patients and workers exposed to silica dust to study the role of TGF-beta1 and TNF-alpha in the development of silicosis.

METHODS

One hundred non-exposed workers were selected as control group, 200 workers exposed to silica dust for more than 1 year as exposed group, 32 suspected silicosis patients (originally diagnosed as 0+) as observing group, 130 silicosis patients were as silicosis group. Serum TGF-beta1 and TNF-alpha in each group were determined with ELISA.

RESULTS

Serum TNF-alpha in exposed group [(47.86 +/- 16.52) pg/ml], observing group [(109.11 +/- 31.08) pg/ml], silicosis group [(216.35 +/- 51.03) pg/ml] were significantly higher than that in control group [(6.90 +/- 2.24) pg/ml] (P < 0.01); Silicosis group and observing group were also higher than exposed group (P < 0.01, P < 0.05). Compared with control group [(23.28 +/- 12.24) pg/ml] and exposed group [(29.31 +/- 14.52) pg/ml], serum TGF-beta1 in silicosis group was much higher (P < 0.01).

CONCLUSION

TGF-beta1, and TNF-alpha were essential in the development of silicosis, so the detection of TGF-beta1 and TNF-alpha in peripheral blood was very useful for occupational health surveillance and early diagnosis of silicosis.

摘要

目的

观察矽肺患者及接触矽尘工人血清转化生长因子β1（TGF-β1）和肿瘤坏死因子α（TNF-α）水平，探讨TGF-β1和TNF-α在矽肺发生发展中的作用。

方法

选取100名未接触者作为对照组，200名接触矽尘1年以上工人作为接触组，32名疑似矽肺患者（原诊断为0+）作为观察组，130名矽肺患者作为矽肺组。采用酶联免疫吸附测定法（ELISA）检测各组血清TGF-β1和TNF-α水平。

结果

接触组血清TNF-α水平为（47.86±16.52）pg/ml，观察组为（109.11±31.08）pg/ml，矽肺组为（216.35±51.03）pg/ml，均显著高于对照组的（6.90±2.24）pg/ml（P<0.01）；矽肺组和观察组也高于接触组（P<0.01，P<0.05）。矽肺组血清TGF-β1水平较对照组的（23.28±12.24）pg/ml和接触组的（29.31±14.52）pg/ml显著升高（P<0.01）。