Strazhenskikh A N, Molokova O A, Chabanov M K, Bychkov V G, Iarotskiĭ L S
Med Parazitol (Mosk). 1990 Jul-Aug(4):39-41.
Intensive and extensive efficacy of praziquantel pure and that included in multilamellar liposomes was studied. As a result, a high anti-helminthic activity of liposomal praziquantel has been established. Negative effect of praziquantel on protein synthetic and enzymatic function of the liver has been revealed in normal animals. The treatment with liposomal praziquantel led to a rapid normalization of total lipid and bilirubin levels, thymol turbidity test, transaminase indices and also to a decrease in dystrophic liver changes.
研究了吡喹酮纯品及其多层脂质体包封物的强化和广泛疗效。结果表明，脂质体吡喹酮具有很高的抗蠕虫活性。在正常动物中已发现吡喹酮对肝脏蛋白质合成和酶功能有负面影响。脂质体吡喹酮治疗可使总脂质和胆红素水平、麝香草酚浊度试验、转氨酶指标迅速恢复正常，并减少肝脏营养不良性变化。
