Zhang Yi, Cao Lu-hong, Chen Qun, Chen Xiao-ping, Xu Wei-hua, Fang Qin, Zhang Jing-fei, Sun Na, Sun Guang-bin
Department of Otorhinolaryngology, Gongli Hospital Pudong New Area, Shanghai, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Dec;46(12):1039-41.
To observe the injury and repair of the subepithelial cordectomy by CO2 laser in different power.
Thirty dogs were randomly divided into 5 groups according to different laser power such as A(1 W), B(3 W), C(5 W), D(8 W), E(cold instruments), 6 dogs in each group. Subepithelial cordectomy was performed on the dogs and the tissue damage and wound recovery were observed in different time after operation.
The mucosa reaction in group C, D was heavier than those in group A, B, E, and the wounds healed slowly with visible pathological scars. The densities of fibroblast and blood capillary were determined with optical microscope. It was found that those in group C, D were higher than those in group A, B, E. The difference was statistically significant (average P < 0.05). Observation by electron microscope showed that the injuries were lighter in group A, B, E and there was no significant difference in vocal cord repair process, while the injuries were more serious in group C, D with few elastic fibers in lamina propria and collagen fibers increased significantly after vocal cord repairing.
The tissue repair after subepithelial cordectomy by CO2 laser with low power (1 - 3 W) was similar to that by cold instrument surgery.
观察不同功率二氧化碳激光行上皮下声带切除术的损伤及修复情况。
30只犬按激光功率不同随机分为5组，即A组（1W）、B组（3W）、C组（5W）、D组（8W）、E组（冷器械组），每组6只。对犬行上皮下声带切除术，观察术后不同时间的组织损伤及创面恢复情况。
C组、D组黏膜反应较A组、B组、E组重，创面愈合慢，有明显病理瘢痕。光镜下测定成纤维细胞及毛细血管密度，发现C组、D组高于A组、B组、E组，差异有统计学意义（平均P<0.05）。电镜观察显示，A组、B组、E组损伤较轻，声带修复过程无明显差异，而C组、D组损伤较重，固有层弹性纤维少，声带修复后胶原纤维明显增多。
低功率（1 - 3W）二氧化碳激光行上皮下声带切除术后组织修复情况与冷器械手术相似。
