Li Na, Wang Li, Ding Hu, Wang Zhong, Wang Dao-wen, Xu Yu-jun, Zhang Wang-qiang, Duan Jun-cang, Wang Yue-hong
Department of Cardiology, the First Affiliated Hospital, Medical College of Shihezi University, Shihezi 832008, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2011 Dec;39(12):1101-4.
To investigate the association between rs751141 gene polymorphisms in EPHX2 gene and essential hypertension in Kazak and Han in Xinjiang.
A total of 267 essential hypertensive patients in Kazaks, 368 essential hypertensive patients in Hans, 284 normotensive controls in Kazaks and 348 normotensive controls in Hans were enrolled in this study. TaqMan assay was used to detect the rs751141 G/A gene polymorphisms of EPHX2 gene.
The rs751141 G/A genotype frequencies for GA + AA genotypes was 40.2 percent in essential hypertensive subjects and 52.0 percent in control subjects in Hans, respectively. The genotype frequencies were significant difference between the two groups in Hans in Xinjiang (P < 0.01). The rs751141G/A gene polymorphism had no significant difference between essential hypertensive patients and normotensive controls in Kazaks in Xinjiang (P > 0.05).
The essential hypertension in Kazaks in Xinjiang is not associated with rs751141G/A gene polymorphism of EPHX2 gene, but the essential hypertension in Hans in Xinjiang is associated with rs751141G/A allele gene polymorphism of EPHX2 gene. A type of rs751141 allele gene polymorphism may be the independent protective factor of essential hypertension in Hans in Xinjiang.
探讨新疆哈萨克族和汉族人群中EPHX2基因rs751141基因多态性与原发性高血压的关系。
本研究纳入267例哈萨克族原发性高血压患者、368例汉族原发性高血压患者、284例哈萨克族血压正常对照者和348例汉族血压正常对照者。采用TaqMan分析法检测EPHX2基因rs751141 G/A基因多态性。
汉族原发性高血压患者中GA + AA基因型的rs751141 G/A基因型频率分别为40.2%，血压正常对照者中为52.0%。新疆汉族两组间基因型频率差异有统计学意义（P < 0.01）。新疆哈萨克族原发性高血压患者与血压正常对照者之间rs751141G/A基因多态性差异无统计学意义（P > 0.05）。
新疆哈萨克族原发性高血压与EPHX2基因rs751141G/A基因多态性无关，但新疆汉族原发性高血压与EPHX2基因rs751141G/A等位基因多态性有关。rs751141等位基因多态性可能是新疆汉族原发性高血压的独立保护因素。
