Fernandez Ritin, Griffiths Rhonda
School of Nursing, Midwifery and Indigenous Health, University of Wollongong, Kogarah,
Cochrane Database Syst Rev. 2012 Feb 15(2):CD003861. doi: 10.1002/14651858.CD003861.pub3.
Although various solutions have been recommended for cleansing wounds, normal saline is favoured as it is an isotonic solution and does not interfere with the normal healing process. Tap water is commonly used in the community for cleansing wounds because it is easily accessible, efficient and cost effective; however, there is an unresolved debate about its use.
The objective of this review was to assess the effects of water compared with other solutions for wound cleansing.
For this fourth update we searched the Cochrane Wounds Group Specialised Register (searched 9 November 2011); The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 4); Ovid MEDLINE (2010 to October Week 4 2011); Ovid MEDLINE (In-Process & Other Non-Indexed Citations, November 8, 2011); Ovid EMBASE (2010 to 2011 Week 44); and EBSCO CINAHL (2010 to 4 November 2011).
Randomised and quasi randomised controlled trials that compared the use of water with other solutions for wound cleansing were eligible for inclusion. Additional criteria were outcomes that included objective or subjective measures of wound infection or healing.
Two review authors independently carried out trial selection, data extraction and quality assessment. We settled differences in opinion by discussion. We pooled some data using a random-effects model.
We included 11 trials in this review. We identified seven trials that compared rates of infection and healing in wounds cleansed with water and normal saline; three trials compared cleansing with no cleansing and one trial compared procaine spirit with water. There were no standard criteria for assessing wound infection across the trials, which limited the ability to pool the data. The major comparisons were water with normal saline, and tap water with no cleansing. For chronic wounds, the relative risk of developing an infection when cleansed with tap water compared with normal saline was 0.16, (95% CI 0.01 to 2.96). Tap water was more effective than saline in reducing the infection rate in adults with acute wounds (RR 0.63, 95% CI 0.40 to 0.99). The use of tap water to cleanse acute wounds in children was not associated with a statistically significant difference in infection when compared to saline (RR 1.07, 95% CI 0.43 to 2.64). We identified no statistically significant differences in infection rates when wounds were cleansed with tap water or not cleansed at all (RR 1.06, 95% CI 0.07 to 16.50). Likewise, there was no difference in the infection rate in episiotomy wounds cleansed with water or procaine spirit. The use of isotonic saline, distilled water and boiled water for cleansing open fractures also did not demonstrate a statistically significant difference in the number of fractures that were infected.
AUTHORS' CONCLUSIONS: There is no evidence that using tap water to cleanse acute wounds in adults increases infection and some evidence that it reduces it. However there is not strong evidence that cleansing wounds per se increases healing or reduces infection. In the absence of potable tap water, boiled and cooled water as well as distilled water can be used as wound cleansing agents.
尽管已推荐多种溶液用于伤口清洗,但生理盐水因其为等渗溶液且不干扰正常愈合过程而备受青睐。自来水在社区中常用于伤口清洗,因为其易于获取、高效且具有成本效益;然而,关于其使用仍存在未解决的争议。
本综述的目的是评估与其他溶液相比,水用于伤口清洗的效果。
对于本次第四次更新,我们检索了Cochrane伤口小组专业注册库(检索日期为2011年11月9日);Cochrane对照试验中央注册库(CENTRAL)(《Cochrane图书馆》2011年第4期);Ovid MEDLINE(2010年至2011年10月第4周);Ovid MEDLINE(在研及其他未索引引用文献,2011年11月8日);Ovid EMBASE(2010年至2011年第44周);以及EBSCO CINAHL(2010年至2011年11月4日)。
将水与其他溶液用于伤口清洗进行比较的随机和半随机对照试验符合纳入标准。其他标准为包括伤口感染或愈合的客观或主观测量的结局。
两位综述作者独立进行试验选择、数据提取和质量评估。我们通过讨论解决意见分歧。我们使用随机效应模型汇总了一些数据。
本综述纳入了11项试验。我们确定了7项比较用水和生理盐水清洗伤口的感染率和愈合率的试验;3项试验比较了清洗与未清洗,1项试验比较了普鲁卡因酒精与水。各试验在评估伤口感染方面没有标准标准,这限制了汇总数据的能力。主要比较为水与生理盐水,以及自来水与未清洗。对于慢性伤口,与生理盐水相比,用自来水清洗时发生感染的相对风险为0.16(95%可信区间0.01至2.96)。在减少急性伤口成人的感染率方面,自来水比生理盐水更有效(风险比0.63,95%可信区间0.40至0.99)。与生理盐水相比,用自来水清洗儿童急性伤口在感染方面未显示出统计学上的显著差异(风险比1.07,95%可信区间0.43至2.64)。我们发现用自来水清洗伤口与根本不清洗伤口在感染率上没有统计学上的显著差异(风险比1.06,95%可信区间0.07至16.50)。同样,用水或普鲁卡因酒精清洗会阴切开伤口的感染率没有差异。使用等渗盐水、蒸馏水和开水清洗开放性骨折在感染的骨折数量上也未显示出统计学上的显著差异。
没有证据表明用自来水清洗成人急性伤口会增加感染,且有一些证据表明会减少感染。然而,没有有力证据表明伤口清洗本身会促进愈合或减少感染。在没有可饮用自来水的情况下,凉开水和蒸馏水可用作伤口清洗剂。