三-O-胸苷在 HPLC 手性固定相上的动态色谱行为。
The dynamic chromatographic behavior of tri-o-thymotide on HPLC chiral stationary phases.
机构信息
Sapienza Università di Roma, Dipartimento di Chimica e Tecnologie del Farmaco, P.le A. Moro 5, 00185, Rome, Italy.
出版信息
Chem Commun (Camb). 2012 Mar 28;48(26):3167-9. doi: 10.1039/c2cc00021k. Epub 2012 Feb 16.
PMID:22337342
Abstract
The interconverting stereoisomers of tri-o-thymotide have been separated by HPLC on chiral stationary phases and the temperature dependence of the dynamic chromatographic patterns has been interpreted in terms of exchange between enantiomeric propeller and helical conformations. Computed low energy structures and CD spectra were used in absolute configuration assignment.
摘要
三-O-胸苷酸的互变立体异构体已通过手性固定相 HPLC 分离，并根据对映桨型和螺旋构象之间的交换解释了动态色谱模式的温度依赖性。计算的低能量结构和 CD 光谱用于绝对构型的归属。
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