Greene Arin K
Department of Plastic and Oral Surgery, Vascular Anomalies Center, Children's Hospital Boston, Boston, Massachusetts 02115, USA.
J Craniofac Surg. 2012 Jan;23(1):220-4. doi: 10.1097/SCS.0b013e318241b8cc.
The field of vascular anomalies is confusing because numerous types of lesions exist, different anomalies often look similar, and imprecise terminology commonly is used. Pharmacotherapy is effective for certain vascular tumors; sclerotherapy generally is the primary treatment of problematic lymphatic and venous malformations. Arteriovenous malformations remain difficult to manage because of their high progression and recurrence rates. Propranolol has gained popularity recently for the treatment of problematic infantile hemangioma, but its efficacy and safety compared with corticosteroid therapy have not been studied. Continuing education is needed to increase the use of accepted biologic terms to describe vascular anomalies; this will improve patient care and facilitate research. As vascular anomalies centers continue to develop, children will have easier access to interdisciplinary expertise. Patients are most likely to be diagnosed and treated properly when managed by a specialist or team focused on these conditions. Recent insight into the etiopathogenesis of infantile hemangioma and vascular malformations may lead to novel therapies for these lesions in the near future.
血管异常领域令人困惑，因为存在多种类型的病变，不同的异常往往看起来相似，而且常用术语不准确。药物治疗对某些血管肿瘤有效；硬化疗法通常是有问题的淋巴管和静脉畸形的主要治疗方法。动静脉畸形由于其高进展和复发率，仍然难以处理。普萘洛尔最近在治疗有问题的婴儿血管瘤方面受到欢迎，但与皮质类固醇疗法相比，其疗效和安全性尚未得到研究。需要持续开展教育，以增加使用公认的生物学术语来描述血管异常；这将改善患者护理并促进研究。随着血管异常中心的不断发展，儿童将更容易获得跨学科专业知识。由专注于这些病症的专家或团队进行管理时，患者最有可能得到正确的诊断和治疗。最近对婴儿血管瘤和血管畸形的病因发病机制的深入了解可能在不久的将来导致针对这些病变的新疗法。
