The Walton Centre NHS Foundation Trust, Liverpool, L9 7LJ, UK.
Eur J Pain. 2012 Apr;16(4):550-61. doi: 10.1002/j.1532-2149.2011.00064.x. Epub 2011 Dec 19.
There is good evidence from studies conducted in a single-centre research setting for the efficacy of graded motor imagery (GMI) treatment, a complex physiotherapy intervention, to reduce pain in long-standing complex regional pain syndrome (CRPS). However, whether GMI is effective in clinical practice is not established.
To establish whether GMI is effective in clinical practice.
We undertook a prospective audit of GMI treatment at two UK centres with a special interest in the management of patients with CRPS. All patients received GMI, in conjunction with a range of other 'best practice' physical and psychological interventions.
The patients' average pain intensities did not improve with treatment [centre 1: n = 20, pre-post numeric rating scale (NRS) difference 0.6 [confidence interval (CI) -0.3 to 1.5]; centre 2: n = 12, pre-post NRS difference 0.2 (CI: -0.9 to 1.2)]. Patients at centre 1 reported significant functional improvement. Improved performance on left/right judgement replicated in both centres seen in the clinical trials.
The failure of our real-world implementation of GMI suggests that better understanding of both the GMI methodology and its interaction with other treatment methods is required to ensure that GMI research results can be translated into clinical practice. Our results highlight challenges with the translation of complex interventions for chronic pain conditions into clinical practice.
在单中心研究环境中进行的研究为分级运动想象(GMI)治疗的疗效提供了充分的证据,这是一种复杂的物理治疗干预措施,可减轻长期复杂区域疼痛综合征(CRPS)的疼痛。然而,GMI 在临床实践中是否有效尚未确定。
确定 GMI 在临床实践中的有效性。
我们在英国的两个中心对 GMI 治疗进行了前瞻性审核,特别关注 CRPS 患者的管理。所有患者都接受了 GMI 治疗,并结合了一系列其他“最佳实践”的身体和心理干预措施。
患者的平均疼痛强度并未随着治疗而改善[中心 1:n=20,数字评分量表(NRS)前后差值为 0.6(置信区间(CI)-0.3 至 1.5);中心 2:n=12,NRS 前后差值为 0.2(CI:-0.9 至 1.2)]。中心 1 的患者报告了显著的功能改善。临床试验中在两个中心都观察到的左右判断的改善表现得到了复制。
我们对 GMI 的实际实施的失败表明,需要更好地理解 GMI 方法及其与其他治疗方法的相互作用,以确保 GMI 研究结果能够转化为临床实践。我们的结果强调了将复杂干预措施转化为慢性疼痛疾病的临床实践所面临的挑战。