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本文引用的文献

1
Management of massive pulmonary embolism: a retrospective single-centre cohort study.大面积肺栓塞的治疗：一项回顾性单中心队列研究。
Crit Care Resusc. 2010 Dec;12(4):242-7.
2
[Guidelines on the diagnosis and management of acute pulmonary embolism].[急性肺栓塞诊断与管理指南]
G Ital Cardiol (Rome). 2009 May;10(5):303-47.
3
Data from a national lung cancer registry contributes to improve outcome and quality of surgery: Danish results.来自国家肺癌登记处的数据有助于改善手术效果和质量：丹麦的结果。
Eur J Cardiothorac Surg. 2009 Feb;35(2):348-52; discussion 352. doi: 10.1016/j.ejcts.2008.09.026. Epub 2008 Dec 12.
4
Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).静脉血栓栓塞的预防：美国胸科医师学会循证临床实践指南（第8版）
Chest. 2008 Jun;133(6 Suppl):381S-453S. doi: 10.1378/chest.08-0656.
5
Incidence of venous thromboembolism in patients undergoing thoracotomy for lung cancer.接受肺癌开胸手术患者的静脉血栓栓塞发生率。
J Thorac Cardiovasc Surg. 2008 Mar;135(3):705-6. doi: 10.1016/j.jtcvs.2007.10.036.
6
Efficacy of thrombolytic agents in the treatment of pulmonary embolism.溶栓药物治疗肺栓塞的疗效
Eur Respir J. 2005 Nov;26(5):864-74. doi: 10.1183/09031936.05.00002505.
7
Low-molecular-weight heparin compared with intravenous unfractionated heparin for treatment of pulmonary embolism: a meta-analysis of randomized, controlled trials.低分子量肝素与静脉注射普通肝素治疗肺栓塞的比较：随机对照试验的荟萃分析
Ann Intern Med. 2004 Feb 3;140(3):175-83. doi: 10.7326/0003-4819-140-3-200402030-00008.
8
Successful management of acute pulmonary embolism after surgery for lung cancer.肺癌手术后急性肺栓塞的成功管理。
Eur J Cardiothorac Surg. 2003 Oct;24(4):580-7. doi: 10.1016/s1010-7940(03)00392-0.

肺叶切除术后5天成功溶栓治疗大面积肺栓塞

Successful thrombolysis of major pulmonary embolism 5 days after lobectomy.

作者信息

Eckardt Jens, Licht Peter B

机构信息

Department of Cardiothoracic Surgery, Odense University Hospital, Odense, Denmark.

出版信息

Interact Cardiovasc Thorac Surg. 2012 May;14(5):660-1. doi: 10.1093/icvts/ivs002. Epub 2012 Feb 15.

DOI:10.1093/icvts/ivs002
PMID:22338043
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3329299/
Abstract

Aggressive intravenous thrombolysis of pulmonary emboli after major thoracic surgery has rarely been reported and is controversial because of an assumed risk of fatal bleeding. We report a 62-year old female who underwent left upper lobectomy. Her postoperative course was complicated with symptomatic pulmonary embolism and on postoperative day 5 she was successfully treated with intravenous thrombolysis using alteplase (Actilyse(®)) without signs of bleeding. She was discharged from the hospital 12 days postoperatively.

摘要

重大胸外科手术后对肺栓塞进行积极静脉溶栓治疗的报道很少，且因存在致命性出血风险而颇具争议。我们报告一例62岁女性患者，她接受了左上肺叶切除术。术后出现有症状的肺栓塞，术后第5天使用阿替普酶（爱通立（®））进行静脉溶栓治疗成功，且无出血迹象。术后12天她出院。