An Chao, Xu Tao, Wang Xiao-Feng
Department of Urology, Peking University People's Hospital, Beijing 100044, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2011 Oct;33(5):582-6.
Prostate cancer is one of the most common visceral malignancies in human. In recent years, its incidence has dramatically increased in China. 5 alpha-reductase inhibitors can block the biological effects of dihydrotestosterone by restraining the transformation from testosterone to dihydrotestosterone, and therefore can be used for the chemoprevention of prostate cancer. Two large clinical trials on the chemoprevention of prostate cancer (the Prostate Cancer Prevention Trial and the Reduction by Dutasteride of Prostate Cancer Events) were completed in 2003 and 2008, respectively, bringing the global interests on this topic. However, the interpretations of these two trials and the possible recommendations on clinical applications remain controversial.
前列腺癌是人类最常见的内脏恶性肿瘤之一。近年来，其发病率在中国急剧上升。5α-还原酶抑制剂可通过抑制睾酮向二氢睾酮的转化来阻断二氢睾酮的生物学效应，因此可用于前列腺癌的化学预防。两项关于前列腺癌化学预防的大型临床试验（前列腺癌预防试验和度他雄胺降低前列腺癌事件试验）分别于2003年和2008年完成，引发了全球对该主题的关注。然而，对这两项试验的解读以及临床应用的可能建议仍存在争议。
