Kawano Takahisa, Kosuge Takayuki, Takagi Shunsuke, Shimoyama Akira, Harunari Nobuyuki, Tahara Yoshio, Suzuki Noriyuki
Department of Critical Care Medicine, University of Fukui Hospital.
Chudoku Kenkyu. 2011 Dec;24(4):305-10.
We experienced the first death case of the serotonin syndrome in Japan caused by fluvoxamine and tandospirone. A 15-year-old man was transported to our hospital for shock, muscle hypertonia and hyperthermia after cardiopulmonary arrest. His serum concentrations of fluvoxamine and tandospirone were 3,554 ng/mL and 698 ng/mL respectively after 24 hours from oral intake. He was dead in spite of intensive treatments. The progress of the serotonin syndrome is usually rapid. So, it should be monitored appropriately a patient with serotonin syndrome. If he has hyperthermia, immediate paralysis should be induced. We should aware of the serotonin syndrome a case of overdose on a serotonergic agent.
