Fawad Saadia
Department of Gynaecology, Aero Hospital, Air Weapon Complex Hassanabdal, Pakistan.
J Ayub Med Coll Abbottabad. 2010 Jul-Sep;22(3):197-200.
Recurrent pregnancy loss is a major health problem effecting 1(see symbol) 2% of women of reproductive age. Its causes range from chromosomal abnormalities to endocrinological factors and thrombophilia related factors. Treating thrombophilias especially antiphospholipid syndrome with low dose aspirin and low molecular weight heparin improves foetal outcome. This study will add local data to already existing knowledge.
Sixty selected patients from gynaecology OPD of Aero Hospital with clinical and/or serological findings of antiphospholipid syndrome from February 2009 to January 2011 were given aspirin 75 mg once daily and enoxaparine 40 mg subcutaneously once daily from 6-8 weeks to 35 and 37 weeks respectively.
Ninety-three percent of patients achieved live birth. Out of these 75% patients delivered at term and 18% had preterm delivered. Four (7%) had early pregnancy loss and only one had early neonatal death due to extreme prematurity. None of patients experienced any major hemorrhagic complications.
Use of low dose aspirin and low molecular weight heparin is safe in pregnancy and improve foetal outcome in patients with recurrent pregnancy loss due to antiphospholipids syndrome.
复发性流产是一个主要的健康问题，影响着1%至2%的育龄妇女。其病因范围从染色体异常到内分泌因素以及与血栓形成倾向相关的因素。用低剂量阿司匹林和低分子量肝素治疗血栓形成倾向，尤其是抗磷脂综合征，可改善胎儿结局。本研究将为现有知识增添本地数据。
从2009年2月至2011年1月，从航空医院妇科门诊选取60例有抗磷脂综合征临床和/或血清学表现的患者，分别从孕6至8周开始至孕35周和37周，给予阿司匹林75毫克每日一次，依诺肝素40毫克皮下注射每日一次。
93%的患者实现活产。其中75%的患者足月分娩，18%早产。4例（7%）发生早期流产，仅1例因极度早产发生早期新生儿死亡。无患者发生任何严重出血并发症。
低剂量阿司匹林和低分子量肝素在孕期使用安全，可改善因抗磷脂综合征导致复发性流产患者的胎儿结局。
