Vascular Inflammation Group, Institute of Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, D-60590 Frankfurt, Germany.
Curr Vasc Pharmacol. 2012 Sep;10(5):555-62. doi: 10.2174/157016112801784486.
Platelet adhesion on vascular wall is the first step following vascular injury. Differential platelet secretion supports angiogenesis and vascular homeostasis. Progenitor cells are pluripotent cells responsible for tissue regeneration and wound healing. Upon ischemia bone marrow-derived progenitor cells are mobilized into peripheral circulation and domiciliate into peripheral organ vasculature and either give birth to a series of cardiovascular cells, including endothelial cells, macrophages, smooth muscle cells, or support in a paracrinic way the angiogenic capacity of local tissue cells. Mobilization, chemotaxis, adhesion, differentiation and interaction with vascular cells are essential steps of progenitor cell-mediated tissue repair. This review summarizes the recent advances in our understanding of platelet function with focus on interaction with progenitor cells and its role in cardiovascular homeostasis. Moreover, the role of platelet microparticles in progenitor cell function is separately addressed. Understanding the mechanisms of platelet interaction with progenitor cells provides us with new insights in the mechanisms of vascular homeostasis and possible new therapeutical targets supporting vascular repair.
血小板黏附于血管壁是血管损伤后的第一步。血小板的差异化分泌有助于血管生成和血管稳态。前体细胞是多能细胞，负责组织再生和伤口愈合。在缺血的情况下，骨髓来源的前体细胞被动员到外周循环中，并定居在外周器官的血管中，或者产生一系列心血管细胞，包括内皮细胞、巨噬细胞、平滑肌细胞，或者以旁分泌的方式支持局部组织细胞的血管生成能力。动员、趋化、黏附、分化以及与血管细胞的相互作用是前体细胞介导的组织修复的必要步骤。本综述总结了我们对血小板功能的最新认识，重点介绍了血小板与前体细胞的相互作用及其在心血管稳态中的作用。此外，还分别探讨了血小板微粒在前体细胞功能中的作用。了解血小板与前体细胞相互作用的机制为我们提供了关于血管稳态机制的新见解，并为支持血管修复的新治疗靶点提供了可能。
