Department of Psychiatry and Psychotherapy, University of Tübingen, Calwer-Str. 14, D-72076 Tübingen, Germany.
Curr Vasc Pharmacol. 2012 Sep;10(5):626-30. doi: 10.2174/157016112801784657.
Vascular risk factors and atherosclerosis are critically involved in dementia development of both vascular and Alzheimer's type. However, the exact mechanisms linking atherosclerosis and the development of Alzheimer's disease (AD) are still unknown. As platelet activation and adhesion on vascular wall is the first step of vascular inflammation and atherosclerosis, it appears tempting to hypothesize that platelets could be the link between vascular risk factors/ atherosclerosis and AD. In recent years, much work has been accomplished to elucidate the role of platelets in AD. The present review will summarize and highlight the latest findings of this research area and provide novel insight and understanding in the association between platelet activation and AD.
血管危险因素和动脉粥样硬化与血管性和阿尔茨海默病（AD）类型的痴呆发展密切相关。然而，将动脉粥样硬化与 AD 发展联系起来的确切机制尚不清楚。由于血小板在血管壁上的激活和黏附是血管炎症和动脉粥样硬化的第一步，因此可以假设血小板可能是血管危险因素/动脉粥样硬化与 AD 之间的联系。近年来，已经完成了大量工作来阐明血小板在 AD 中的作用。本综述将总结和强调该研究领域的最新发现，并为血小板激活与 AD 之间的关联提供新的见解和理解。
