Department of Oral and Maxillofacial Surgery, College of Stomatology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, PR China.
Anticancer Agents Med Chem. 2012 Oct 1;12(8):994-1000. doi: 10.2174/187152012802650066.
Gambogic acid (GA) is a caged xanthone that is derived from Garcinia hanburyi and functions as a strong apoptotic inducer in many types of cancer cells. The distinct effectiveness of GA has led to its characterization as a novel anti-cancer agent. There is an increasing number of research studies focused on elucidating the molecular mechanisms of GA-induced anti-cancer effects, and several critical signaling pathways have been reported to be influenced by GA treatment. In this review, we summarize the multiple functional effects of GA administration in cancer cells including the induction of apoptosis, the inhibition of proliferation and the prevention of cancer metastasis and tumor angiogenesis.
藤黄酸（GA）是一种笼状的黄烷酮，来源于藤黄属植物，在多种癌细胞中具有很强的凋亡诱导作用。GA 的显著疗效使其成为一种新型抗癌药物。越来越多的研究集中在阐明 GA 诱导抗癌作用的分子机制，据报道，GA 处理会影响几个关键的信号通路。在这篇综述中，我们总结了 GA 在癌细胞中的多种功能作用，包括诱导细胞凋亡、抑制增殖以及预防癌症转移和肿瘤血管生成。
