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Myocardial infarction in a newborn heterozygous for the MTHFR C677T mutation.

作者信息

Clark Amy B, Stokes Theophil A, Krous Henry F, Carbine Douglas N

机构信息

Naval Hospital Oak Harbor, Whidbey Island, WA, USA.

出版信息

Pediatr Dev Pathol. 2012 May-Jun;15(3):232-6. doi: 10.2350/11-09-1088-CR.1. Epub 2012 Feb 17.

DOI:10.2350/11-09-1088-CR.1
PMID:22339112
Abstract

Neonatal myocardial infarction secondary to congenital heart disease, anomalous coronary artery anatomy, thromboembolism, coagulopathy, birth asphyxia, and unknown causes has been previously reported. We now report an infant who suffered a massive myocardial infarction during birth, requiring extensive resuscitation and aggressive management. A thrombus, the origin of which was not detected on autopsy, was found occluding the proximal left coronary artery several hours after birth. Genetic studies revealed a single copy variant of the MTHFR C677T mutation that we speculate may have predisposed the infant to coronary thrombosis.

摘要

相似文献

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引用本文的文献

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2
Myocardial necrosis and infarction in newborns and infants.新生儿及婴儿的心肌坏死与梗死
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