Rheumatology Service and Department of Medicine, Hospital Clinico Universitario, Medical School, Universidad de Santiago de Compostela, Santiago, Spain.
Curr Pharm Biotechnol. 2012 Jun;13(8):1418-25. doi: 10.2174/138920112800784808.
TNF has a critical role in inflammation and immunity, and therapeutic inhibition of TNF with antagonist could potentially lead to immune suppression. Data gathered from clinical trials and clinical observation show a minor but significant increased risk of infections in patients suffering from rheumatic diseases treated with monoclonal TNF antibodies and soluble TNF receptors. This increase risk applies to patients but also to the underlying disease. Pathogens causing these infections include intracellular bacteria, and to some extend opportunistic microorganisms as mycobacteria and fungi. Preventive strategies and patient selection have an important impact on the risk of these infections.
TNF 在炎症和免疫中具有关键作用，而使用拮抗剂抑制 TNF 可能会导致免疫抑制。从临床试验和临床观察中收集的数据表明，接受单克隆 TNF 抗体和可溶性 TNF 受体治疗的风湿性疾病患者感染的风险虽小，但意义重大。这种风险不仅适用于患者，也适用于潜在疾病。引起这些感染的病原体包括细胞内细菌，在某种程度上还包括分枝杆菌和真菌等机会性微生物。预防策略和患者选择对这些感染的风险有重要影响。
