Cancer Research Institute, Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia.
Biochemistry (Mosc). 2012 Jan;77(1):111-8. doi: 10.1134/S0006297912010142.
Here we attempt to supplement the metastatic niche concept with a stage of "preniche" that determines the site of development of a premetastatic niche and of a subsequent metastasis. The "preniche" includes all cellular and molecular events in the site of a prospective metastasis preceding the entrance of myeloid progenitor cells. The "preniche" integrates an activation of vascular endothelium of the microcirculatory vessels of target organs in the site of a future metastasis under conditions of chronic persistent productive inflammation that can be induced by cytokines from the primary tumor and independently of it. The endothelium activation is responsible for adhesion and clustering of the recruited myeloid progenitor cells and also for the retention of cells of malignant tumors. The preniche easily arises in organs enriched with organ-specific macrophages (lungs, liver, brain, etc.) where the endothelium is predisposed for intensive recruiting of myeloid progenitor cells of macrophages, especially under conditions of inflammation. Introduction of the "preniche" concept allows us to avoid difficulties associated with the development of the metastatic niche concept, especially concerning the problem of organ-preferential localization of metastases, and to make some predictions for experimental verification and potential approaches for preventing metastasizing in some oncologic patients.
在这里，我们试图用“前生态位”阶段来补充转移生态位的概念，这个阶段决定了前转移生态位和随后转移的发展部位。“前生态位”包括在骨髓祖细胞进入之前，在未来转移部位的靶器官微循环血管中，所有与细胞和分子相关的事件。在由原发性肿瘤及其独立产生的细胞因子诱导的慢性持续性生产性炎症条件下，“前生态位”整合了靶器官中未来转移部位的微血管内皮细胞的激活。内皮细胞的激活负责募集的骨髓祖细胞的黏附和聚集，也负责保留恶性肿瘤细胞。“前生态位”很容易在富含器官特异性巨噬细胞的器官中出现（肺、肝、脑等），在这些器官中，内皮细胞更容易募集巨噬细胞的骨髓祖细胞，尤其是在炎症条件下。引入“前生态位”概念可以避免与转移生态位概念发展相关的困难，特别是与转移的器官偏好性定位问题相关的困难，并为实验验证和某些预防某些肿瘤患者转移的潜在方法提供一些预测。
