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结核分枝杆菌中 meso-二氨基庚二酸（DAP）生物合成酶的结构与功能。

Structure and function of Mycobacterium tuberculosis meso-diaminopimelic acid (DAP) biosynthetic enzymes.

机构信息

School of Biosciences, University of Birmingham, Birmingham, UK.

出版信息

FEMS Microbiol Lett. 2012 May;330(1):10-6. doi: 10.1111/j.1574-6968.2012.02527.x. Epub 2012 Mar 7.

DOI:10.1111/j.1574-6968.2012.02527.x
PMID:22339732
Abstract

Because of an increased emergence of resistance to current antitubercular drugs, there is a need for new antitubercular agents directed against novel targets. Diaminopimelic acid (DAP) biosynthetic enzymes are unique to bacteria and are absent in mammals and provide a rich source of essential targets for antitubercular chemotherapy. Herein, we review the structure and function of the mycobacterial DAP biosynthetic enzymes.

摘要

由于当前抗结核药物的耐药性不断增加，因此需要针对新靶标开发新的抗结核药物。二氨基庚二酸（DAP）生物合成酶是细菌所特有的，而在哺乳动物中不存在，为抗结核化疗提供了丰富的必需靶标来源。本文综述了分枝杆菌 DAP 生物合成酶的结构和功能。

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